64987-03-7

Basic information

• Product Name: ETHYL 2-(2-FORMYLAMINO-1,3-THIAZOL-4-YL)-2-OXOACETATE
• Synonyms: (2-FORMYLAMINOTHIAZOL-4-YL)-OXO-ACETIC ACID ETHYL ESTER;LABOTEST-BB LT00441209;ETHYL 2-(FORMYLAMINO)-4-THIAZOLEGLYOXYLATE;ETHYL 2-(2-FORMAMIDO-1,3-THIAZOL-4-YL)-2-OXO-ACETATE;ETHYL 2-(2-FORMYLAMINO-1,3-THIAZOL-4-YL)-2-OXOACETATE;ETHYL-2-(2-FORMYLAMINO-4-THIAZOLE-4-YL)-1-OXY ACETATE;ETHYL 2-(2-FORMYLAMINOTHIAZOL-4-YL) GLYOXYLATE;ethyl 2-formamido-alpha-oxothiazol-4-acetate
• CAS NO: 64987-03-7
• Molecular Formula: C₈H₈N₂O₄S
• Molecular Weight: 228.23
• EINECS: 265-299-4
• Mol File: 64987-03-7.mol
• Article Data: 5

Chemical Properties

• Melting Point: 232-234 °C
• Boiling Point: 381.313 °C at 760 mmHg
• Flash Point: 184.412 °C
• Appearance: light yellow powder
• Density: 1.5150 (rough estimate)
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.5690 (estimate)
• Storage Temp.: 2-8°C
• Solubility: Chloroform (Slightly, Heated), DMSO (Slightly)
• PKA: 8.11±0.70(Predicted)
• CAS DataBase Reference: ETHYL 2-(2-FORMYLAMINO-1,3-THIAZOL-4-YL)-2-OXOACETATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 2-(2-FORMYLAMINO-1,3-THIAZOL-4-YL)-2-OXOACETATE(64987-03-7)
• EPA Substance Registry System: ETHYL 2-(2-FORMYLAMINO-1,3-THIAZOL-4-YL)-2-OXOACETATE(64987-03-7)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 36/37/38-22
• Safety Statements: 36/37/39-26-37/39
• Hazardous Substances Data: 64987-03-7(Hazardous Substances Data)

Usage

Chemical Properties

light yellow powder

Uses

Ethyl 2-(2-Formamidothiazol-4-yl)-2-oxoacetate is an intermediate formed in the synthesis of Cefixime Ethyl Ester Sodium Salt (C242830), an ester impurity of the third generation cephalosporin antibiotic, Cefixime (C242800).

InChI:InChI=1/C8H8N2O4S/c1-2-14-7(13)6(12)5-3-15-8(10-5)9-4-11/h3-4H,2H2,1H3,(H,9,10,11)

Upstream product

• 64987-05-9 ethyl 2-(2-formylaminothiazol-4-yl)acetate 
• 6156-78-1 manganese (II) acetate tetrahydrate 

Downstream Products

• 64987-06-0 2-(2-formylamino-1,3-thiazol-4-yl)glyoxylic acid 

Relevant articles and documents

Synthesis and Pharmacological Evaluation of a New Class of 2-(2-Aminothiazol-4-yl)-2-hydrazonoacetamido Cephalosporins

A series of 2-(2-aminothiazol-4-yl)-2-hydrazonoacetamido cephalosporins 1a-h was prepared.Whenever possible, E and Z isomers were isolated, and their relative stabilities and their interconversions were tested.The antibacterial activity was tested against Gram-positive and Gram-negative bacteria.For compound 1c, whose Z and E forms do not interconvert rapidly, the Z form was the more active one.Among the other compounds, for which the E form is the only stable one for practical purposes, compound 1a was the most active.When compared with cefuroxime and cefotaxime, compound 1a showed slightly lower antibacterial activity but good serum level and half-life values.

2-Lower alkyl-7-substituted-2 or 3-cephem 4-carboxylic acid compounds

Compounds of the formula: STR1 wherein R1 is (C1 to C6) alkyl. R2 is carboxy or a protected carboxy group, R3 is amino or a protected amino group and A is hydroxyimino (C1 to C6) alkylene or (C1 to C6)-alkoxyimino (C1 to C6) alkylene, and pharmaceutically acceptable salt thereof, have been found to be active against various pathogenic microorganisms.

2-Lower alkyl-7-substituted-2 or 3-cephem-4-carboxylic acid compounds and pharmaceutical compositions

A compound of the formula: STR1 wherein R1 is (C1 to C6) alkyl, R2 is a carboxy or a protected carboxy group, R3 is amino or a protected amino group and A is hydroxyimino (C1 to C6) alkylene or (C1 to C6)-alkoxyimino (C1 to C6)alkylene, And pharmaceutically acceptable salt thereof.