64994-51-0Relevant academic research and scientific papers
Color tuning in new metal-free organic sensitizers (Bodipys) for dye-sensitized solar cells
Kumaresan, Duraisamy,Thummel, Randolph P.,Bura, Thomas,Ulrich, Gilles,Ziessel, Raymond
, p. 6335 - 6339 (2009)
The use of highly fluorescent Bodipy dyes engineered from a single organic core (the dipyrromethene moiety), in which the color could be tuned by tailoring the periphery with styryl arms, was demonstrated. The pseudo-central meso position was used to intr
Preparation, Photophysical and Electrochemical Evaluation of an Azaborondipyrromethene/Zinc Porphyrin/Graphene Supramolecular Nanoensemble
Rotas, Georgios,Thomas, Michael B.,Canton-Vitoria, Ruben,D'Souza, Francis,Tagmatarchis, Nikos
, p. 6652 - 6661 (2020/04/24)
The preparation of an entirely supramolecular, multichromophoric azaborondipyrromethene (ABDP)/zinc tetraphenylporphyrin (ZnTPP)/exfoliated graphene (GR) nanoensemble was accomplished. The ABDP derivative bears glycol chains for enhancing solubility and a
The influence of polyether substituents on biological activity of curcumin derivatives
Deptula, Tomasz,Krwczyski, Adam,Bubko, Irena,Gruber-Bzura, Beata Maria
, p. 99 - 111 (2020/04/10)
Curcumin is reported as an anti-proliferative and chemopreventive compound. However, it shows poor water solubility, low bioavailability, and rapid metabolism. To address these problems, curcumin derivatives substituted with polyether chain were synthesiz
METAL ORGANIC LIQUID CRYSTAL DYES
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Paragraph 0074; 0075, (2018/01/14)
A dye composition dissolvable within a liquid crystal host device (including: polymer dispersed liquid crystal, polymer network liquid crystal, polymer stabilized liquid crystal, liquid crystal displays and similar devices), comprising eutectic mixtures o
A toolbox for controlling the properties and functionalisation of hydrazone-based supramolecular hydrogels
Poolman, Jos M.,Maity, Chandan,Boekhoven, Job,Van Der Mee, Lars,Le Sage, Vincent A.A.,Groenewold, G.J. Mirjam,Van Kasteren, Sander I.,Versluis, Frank,Van Esch, Jan H.,Eelkema, Rienk
supporting information, p. 852 - 858 (2016/02/05)
In recent years, we have developed a low molecular weight hydrogelator system that is formed in situ under ambient conditions through catalysed hydrazone formation between two individually non-gelating components. In this contribution, we describe a molecular toolbox based on this system which allows us to (1) investigate the limits of gel formation and fine-tuning of their bulk properties, (2) introduce multicolour fluorescent probes in an easy fashion to enable high-resolution imaging, and (3) chemically modify the supramolecular gel fibres through click and non-covalent chemistry, to expand the functionality of the resultant materials. In this paper we show preliminary applications of this toolbox, enabling covalent and non-covalent functionalisation of the gel network with proteins and multicolour imaging of hydrogel networks with embedded mammalian cells and their substructures. Overall, the results show that the toolbox allows for on demand gel network visualisation and functionalisation, enabling a wealth of applications in the areas of chemical biology and smart materials.
Homoserine lactone derivatives, preparation method thereof and pharmaceutical composition for prevention or treatment of the periodontal diseases containing the same as an active ingredient
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Paragraph 0293-0296, (2017/04/14)
The present invention relates to homoserine lactone derivatives, optical isomers of the same, or pharmaceutically acceptable salts of the same. The homoserine lactone derivatives in the present invention have excellent properties as a quorum sensing antagonist which hinders communications among bacteria. According to the present invention, the homoserine lactone derivatives can hinder gene expressions of bacteria while effectively blocking formation of biofilm which is known to raise resistance against antibiotics, and suppress propagation of bacteria, thereby being useful as a pharmaceutical composition for preventing or treating periodontal diseases.
Visible light-absorbing rhenium(i) tricarbonyl complexes as triplet photosensitizers in photooxidation and triplet-triplet annihilation upconversion
Yi, Xiuyu,Zhao, Jianzhang,Sun, Jifu,Guo, Song,Zhang, Hongli
supporting information, p. 2062 - 2074 (2013/02/26)
We prepared N^N Re(i) tricarbonyl chloride complexes (Re-1 and Re-2) that give very strong absorption of visible light. To this end, it is for the first time that boron dipyrimethane (Bodipy) was used to prepare Re(i) tricarbonyl chloride complexes. The π-conjugation linker between the π-conjugation framework of the antenna Bodipy and the Re(i) coordination centre ensures efficient intersystem crossing (ISC). Re-0 without visible light-harvesting ligand was prepared as a model complex in the photophysical studies. Re-1 (with Bodipy) and Re-2 (with carbazole-ethynyl Bodipy) show unprecedented strong absorption of visible light at 536 nm (ε = 91700 M-1 cm -1) and 574 nm (ε = 64600 M-1 cm-1), respectively. Interestingly, different from Re-0, Re-1 and Re-2 show fluorescence of the ligand, not the phosphorescence of the Re(i) coordination centre. However, long-lived triplet excited states were observed upon visible light excitation (τT = 104.0 μs for Re-1; τT = 127.2 μs for Re-2) vs. the short lifetime of Re-0 (τT = 26 ns). With nanosecond time-resolved transient absorption spectroscopy and DFT calculations, we proved that the triplet excited states of Re-1 and Re-2 are localized on the Bodipy ligands. The complexes were used as triplet photosensitizers for two triplet-triplet-energy-transfer (TTET) processes, i.e.1O2 mediated photooxidation and triplet-triplet annihilation (TTA) upconversion. With the strong visible light-harvesting ability, Re-1 proved to be a better 1O2 photosensitizer than the conventional triplet photosensitizer tetraphenylporphyrin (TPP). Significant upconversion was observed with Re-1 as the triplet photosensitizer. Our result is useful for preparation of Re(i) tricarbonyl chloride complexes that show strong absorption of visible light and long-lived triplet excited states and for the application of these complexes as triplet photosensitizers in photocatalysis, photodynamic therapy and TTA upconversion. The Royal Society of Chemistry 2013.
Synthesis and biological evaluation of novel 4-hydroxybenzaldehyde derivatives as tyrosinase inhibitors
Yi, Wei,Cao, Rihui,Peng, Wenlie,Wen, Huan,Yan, Qin,Zhou, Binhua,Ma, Lin,Song, Huacan
experimental part, p. 639 - 646 (2010/04/02)
A series of novel 4-hydroxybenzaldehyde derivatives were synthesized and their inhibitory effects on the diphenolase activity of mushroom tyrosinase were investigated. Most of target compounds had more potent inhibitory activities than the parent compound 4-hydroxybenzaldehyde (IC50 = 1.22 mM). Interestingly, compound 3c bearing a dimethoxyl phosphate was found to be the most potent inhibitor with IC50 value of 0.059 mM. The inhibition kinetics analyzed by Lineweaver-Burk plots revealed that compound 3c was a non-competitive inhibitor (KI = 0.0368 mM). In particular, compound 3c showed no side effects at dose of 1600 mg/kg in mice. These results suggested that such compounds might be served as lead compounds for further designing new potential tyrosinase inhibitors.
Inhibitory effects of 5-benzylidene barbiturate derivatives on mushroom tyrosinase and their antibacterial activities
Yan, Qin,Cao, Rihui,Yi, Wei,Chen, Zhiyong,Wen, Huan,Ma, Lin,Song, Huacan
experimental part, p. 4235 - 4243 (2009/12/24)
A series of novel 5-benzylidene barbiturate and thiobarbiturate derivatives were synthesized and evaluated as tyrosinase inhibitors and antibacterial agents. The results demonstrated that some compounds had more potent inhibitory activities than the parent compound 4-hydroxybenzaldehyde (IC50 = 1.22 mM). Particularly, compounds 1a and 2a were found to be the most potent inhibitors with IC50 value of 13.98 μM and 14.49 μM, respectively. The inhibition mechanism study revealed that these compounds were irreversible inhibitors. The circular dichroism spectra indicated that these compounds induced conformational changes of mushroom tyrosinase upon binding. In addition, these compounds exhibited selectively antibacterial activity against Staphylococcus aureus. All these results suggested that further development of such compounds may be of interest.
Soluble tetraarylporphyrin-platinum conjugates as cytotoxic and phototoxic antitumor agents
Lottner, Christian,Bart, Karl-Christian,Bernhardt, Günther,Brunner, Henri
, p. 2079 - 2089 (2007/10/03)
A series of asymmetric tetraarylporphyrins was synthesized from pyrrole, para-substituted oligo- or poly(ethylene glycol) monomethyl ether benzaldehyde and from 4-hydroxybenzaldehyde etherified with diethyl bromomalonate according to the Lindsey method. A
