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m-PEG3-Tos is a PEG (polyethylene glycol) linker that incorporates a tosyl group, which serves as an excellent leaving group for nucleophilic substitution reactions. The hydrophilic PEG spacer enhances solubility in aqueous environments, making it a versatile component in various applications.

50586-80-6

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50586-80-6 Usage

Uses

Used in Bioconjugation:
m-PEG3-Tos is used as a bioconjugation agent for attaching biomolecules to other molecules or surfaces. The tosyl group facilitates the coupling process through nucleophilic substitution, while the PEG spacer improves solubility and stability of the resulting conjugates.
Used in Drug Delivery Systems:
In the pharmaceutical industry, m-PEG3-Tos is utilized as a component in drug delivery systems. The PEG spacer enhances the solubility and bioavailability of drugs, while the tosyl group allows for efficient attachment of therapeutic agents to carriers or nanoparticles.
Used in Chemical Synthesis:
m-PEG3-Tos serves as an intermediate in the synthesis of various chemical compounds. The tosyl group's reactivity in nucleophilic substitution reactions makes it a useful building block for creating complex molecules with specific properties.
Used in Materials Science:
In the field of materials science, m-PEG3-Tos is employed in the development of new materials with tailored properties. The PEG spacer can improve the hydrophilicity and processability of materials, while the tosyl group can be used for further functionalization or cross-linking.

Check Digit Verification of cas no

The CAS Registry Mumber 50586-80-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,0,5,8 and 6 respectively; the second part has 2 digits, 8 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 50586-80:
(7*5)+(6*0)+(5*5)+(4*8)+(3*6)+(2*8)+(1*0)=126
126 % 10 = 6
So 50586-80-6 is a valid CAS Registry Number.

50586-80-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-(2-methoxyethoxy)ethanol,4-methylbenzenesulfonic acid

1.2 Other means of identification

Product number -
Other names diethylene glycol monomethyl ether-p-toluene sulfonate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:50586-80-6 SDS

50586-80-6Relevant academic research and scientific papers

Change in the rate of pseudo[1]rotaxane formation by elongating the alkyl-chain-substituted diphenylethynylene linked to permethyl α-cyclodextrin

Ishino, Saqura,Masai, Hiroshi,Shimada, Sotaro,Terao, Jun

, (2020)

Herein, we report the kinetics of pseudo[1]rotaxane formation from permethyl α-cyclodextrin attached to a flexible-chain-substituted diphenylethynylene. When the chain is an alkyl group, the rate of formation shows different trends over three regions of chain length: deceleration (chain length = 1–3), acceleration (4–8), and re-deceleration (>12). This behavior is driven by a relative decrease in the ΔH? of the transition.

Self-assembled amphiphilic water oxidation catalysts: Control of O-O bond formation pathways by different aggregation patterns

Yang, Bing,Jiang, Xin,Guo, Qing,Lei, Tao,Zhang, Li-Ping,Chen, Bin,Tung, Chen-Ho,Wu, Li-Zhu

, p. 6229 - 6234 (2016)

The oxidation of water to molecular oxygen is the key step to realize water splitting from both biological and chemical perspective. In an effort to understand how water oxidation occurs on a molecular level, a large number of molecular catalysts have bee

A water/alcohol-soluble conjugated porphyrin small molecule as a cathode interfacial layer for efficient organic photovoltaics

Zhang, Lin,Liu, Chang,Lai, Tianqi,Huang, Huadong,Peng, Xiaobin,Huang, Fei,Cao, Yong

, p. 15156 - 15161 (2016)

A water/alcohol soluble conjugated porphyrin small molecule, FNEZnP-OE, in which two amino-functionalized fluorenes (9,9-bis(30-(N,N-dimethylamino)propyl)-2,7-fluorenes) are linked to a porphyrin core substituted with two polar 3,4-bis-[2-(2-methoxy-ethoxy)-ethoxy]-phenyls by ethynylene linkages, is designed and synthesized as a cathode interfacial material (CIM) for bulk heterojunction organic solar cells. The PTB7/PC71BM- and PTB7-Th/PC71BM-based devices with FNEZnP-OE as the electron transport layers (ETLs) exhibit power conversion efficiencies (PCEs) of 8.52% and 9.16%, respectively, which are increased by 47% and 41% compared to the devices with no ETL (5.78% and 6.50%, respectively). Most significantly, these PCEs are increased by 13.6% and 8%, respectively, over those with the widely used polymer ETL PFN (poly[(9,9-bis(30-(N,N-dimethylamino)propyl)-2,7-fluorene)-alt-2,7-(9,9-ioctylfluorene)]). The outstanding performance of FNEZnP-OE CIM is contributed by not only the polar groups of 9,9-bis(30-(N,N-dimethylamino)propyl)-2,7-fluorenes and 3,4-bis-[2-(2-methoxy-ethoxy)-ethoxy]-phenyls but also the porphyrin-relating π-conjugated backbone of FNEZnP-OE induced by the ethynylene linkages, demonstrating that functionalized porphyrins are very promising interfacial materials.

Organotin(IV) carboxylate complexes containing polyether oxygen chains with two-photon absorption in the near infrared region and their anticancer activity

Guan, Rongting,Zhou, Ziqi,Zhang, Mingzhu,Liu, Hui,Du, Wei,Tian, Xiaohe,Zhang, Qiong,Zhou, Hongping,Wu, Jieying,Tian, Yupeng

, p. 428 - 437 (2018)

Two novel organo tin carboxylate complexes (BuSnO)6L6 and Bu3SnOL, where L = a cinnamic acid unit containing polyether chains, were rationally designed for two-photon fluorescent imaging and anticancer purpose. The organot

A lysosome-targetable fluorescent probe for real-time imaging cysteine under oxidative stress in living cells

Wang, Xiao-dong,Fan, Li,Ge, Jin-yin,Li, Feng,Zhang, Cai-hong,Wang, Juan-juan,Shuang, Shao-min,Dong, Chuan

, (2019)

As an effective lysosomal biomarker for oxidative stress status, cysteine (Cys)plays an important role in lysosomal proteolysis. Herein, we report the first lysosome-targetable fluorescence probe (MCAB)for Cys-selective detection based on nucleophilic add

1,3-di(ethoxy-ethoxy-methoxy)calix[4]-arene

Guelzim, Abdelhalim,Khrifi, Saad,Baert, Francois,Saadioui, Mohamed,Asfari, Zouhair,Vicens, Jacques

, p. 1958 - 1960 (1997)

In the solid state, the title compound, C38H44O8, adopts a cone conformation, which is somewhat distorted. The cone conformation is also observed by NMR spectroscopy in solution. The distortion consists of a major inward t

Cyanine fluorophores for cellular protection against ROS in stimulated macrophages and two-photon ROS detection

Chan,Xu,Guo,Tam,Liu,Chen,Wong,Lo

, p. 7307 - 7312 (2015)

We report the first example of a novel two-photon active, biocompatible, and macrophage cell-membrane permeable carbazole-based cyanine fluorophore for the detection of three biologically important ROS, namely, ?OH, O2- and OCl- in solution. This versatile probe shows cellular protection not only in stimulated macrophages from phorbol-12-myristate-13-acetate-induced morphological changes but also lipopolysaccharide-induced cytotoxicity by quenching with the O2- and OCl- production, respectively. Such protection could be visualized by a distinct change in the fluorescence intensity of the probe.

Visual monitoring of the lysosomal pH changes during autophagy with a red-emission fluorescent probe

Dong, Chuan,Fan, Li,Liang, Wenting,Shuang, Shaomin,Wang, Xiaodong,Wang, Yubin,Zhang, Caihong

, p. 1466 - 1471 (2020)

Autophagy plays crucial roles in maintaining normal intracellular homeostasis. Molecular probes capable of monitoring lysosomal pH changes during autophagy are still highly required yet challenging to develop. Here, a lysosome-targeting fluorescent pH pro

Self-assembly, conductivity and chemosensor behavior of biphenylsulfone based Janus polycatenar

Cheng, Huifang,Gao, Hongfei,Xiao, Yulong,Zhang, Bei,Xing, Wei,Cheng, Xiaohong

, p. 691 - 698 (2018)

A novel Janus polycatenar JP-I bearing a bisphenylsulfone central core, with a hydrophobic 3,4,5-tridodecyloxybenzylether unit at one side and a hydrophilic trioligoethylene oxide benzyl triazoly unit at another side has been synthesized via copper(I)-cat

Electrochemistry and Optical Absorbance and Luminescence of Molecule-like Au38 Nanoparticles

Lee, Dongil,Donkers, Robert L.,Wang, Gangli,Harper, Amanda S.,Murray, Royce W.

, p. 6193 - 6199 (2004)

This paper describes electrochemical and spectroscopic properties of a well-characterized, synthetically accessible, 1.1 nm diam Au nanoparticle, Au38(PhC2S)24, where PhC2S is phenylethylthiolate. Properties of other Au38 nanoparticles made by exchanging the monolayer ligands with different thiolate ligands are also described. Voltammetry of the Au38 nanoparticles in CH 2Cl2 reveals a 1.62 V energy gap between the first one-electron oxidation and the first reduction. Based on a charging energy correction of ca. 0.29 V, the indicated HOMO-LUMO gap energy is ca. 1.33 eV. At low energies, the optical absorbance spectrum includes peaks at 675 nm (1.84 eV) and 770 nm (1.61 eV) and an absorbance edge at ca. 1.33 eV that gives an optical HOMO-LUMO gap energy that is consistent with the electrochemical estimate. The absorbance at lowest energy is bleached upon electrochemical depletion of the HOMO level. The complete voltammetry contains two separated doublets of oxidation waves, indicating two distinct molecular orbitals, and two reduction steps. The ligand-exchanged nanoparticle Au38(PEG 135S)13(PhC2S)11, where PEG 135S is -SCH2CH2OCH2CH 2OCH3, exhibits a broad (1.77-0.89 eV) near-IR photoluminescence band resolvable into maxima at 902 nm (1.38 eV) and 1025 nm (1.2 eV). Much of the photoluminescence occurs at energies less than the HOMO-LUMO gap energy. A working model of the energy level structure of the Au38 nanoparticle is presented.

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