64995-80-8Relevant academic research and scientific papers
A convenient synthesis of substituted pyrroles from esters of amino acids
Kolar,Tisler
, p. 1887 - 1893 (1994)
A new simple synthesis of substituted pyrroles from alkyl, aryl or heteroaryl substituted α-amino acids is described. Esters of α-amino acids are first reacted with dimethyl acetylenedicarboxylate and in the in situ formed enamines are thereafter cyclized in presence of sodium methoxide to pyrroles.
Efficient strategy for the synthesis of 4-hydroxy-1H-pyrrole-2,3- dicarboxylic ester derivatives using transition-metal-oxide catalysts
Paul, V. Luke,Yakaiah,Reddy, A. Raghuram,Shekhar, A. Chandra,Rao, P. Shanthan,Narsaiah
experimental part, p. 3152 - 3158 (2010/11/18)
A facile and an efficient strategy for the synthesis of multisubstituted pyrrole derivatives was developed using an unusual ring annulation of dialkyl acetylene dicarboxylic ester and-amino acids with transition-metal oxides such as mercuric(II) oxide and silver(I) oxide and complexes such as ceric ammonium nitrate (CAN) and 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (EDCI) as catalysts. Copyright Taylor & Francis Group, LLC.
Synthesis of 4-hydroxy-1H-pyrrole-2,3-dicarboxylic acid derivatives: Unusual coupling of acetylenic esters and α-amino acids in the presence of cyclohexyl isocyanide or N,N′-dicyclohexylcarbodiimide
Alizadeh, Abdolali,Hosseinpour, Reza,Rostamnia, Sadegh
experimental part, p. 2462 - 2466 (2009/04/04)
A facile and direct synthetic entry to 4-hydroxy-1H-pyrrole-2,3- dicarboxylic acid derivatives is reported. It is based on the unusual ring annulation of acetylenic esters and α-amino acids with isocyanide or carbodiimide under neutral conditions in a one-step procedure. Georg Thieme Verlag Stuttgart.
