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Product FOB Price Min.Order Supply Ability Supplier
Hot selling high quality Yohimbine hydrochloride 65-19-0
Cas No: 65-19-0
USD $ 2500.0-2500.0 / Kilogram 1 Kilogram 99999 Kilogram/Year Hangzhou Dingyan Chem Co., Ltd Contact Supplier
Yohimbine hydrochloride
Cas No: 65-19-0
No Data 1 Gram 1-1000 Metric Ton/Day Dayang Chem (Hangzhou) Co.,Ltd. Contact Supplier
Yohimbine hcl
Cas No: 65-19-0
No Data 1 Kilogram 1 Metric Ton/Day Shandong Hanjiang Chemical Co., Ltd. Contact Supplier
High Quality 98%Yohimbine hydrochloride 65-19-0 Reliable Supplier
Cas No: 65-19-0
No Data 10 Gram 500 Kilogram/Week WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD Contact Supplier
Factory bulk supply Yohimbine hydrochloride purity 99% for sexual enhancement
Cas No: 65-19-0
USD $ 1000.0-1100.0 / Kilogram 1 Kilogram 100 Metric Ton/Year Hubei Vanz Pharm Co.,Ltd Contact Supplier
Yohimbine hydrochloride
Cas No: 65-19-0
USD $ 1.0-600.0 / Kilogram 1 Kilogram 1 Metric Ton/Day Kono Chem Co.,Ltd Contact Supplier
Yohimbine HCl CAS NO.65-19-0
Cas No: 65-19-0
USD $ 1.0-3.0 / Kilogram 1 Kilogram 10 Kilogram/Day Hebei yanxi chemical co.,LTD. Contact Supplier
100% Natural Yohimbe Bark Extract Yohimbine hydrochloride Yohimbine HCL Powder 98%
Cas No: 65-19-0
USD $ 1.8-1.96 / Gram 10 Gram 1000 Kilogram/Year Xi'an Quanao Biotech Co., Ltd. Contact Supplier
yohimbe hcl
Cas No: 65-19-0
No Data 1 Kilogram 2 Metric Ton/Year Hefei TNJ chemical industry co.,ltd Contact Supplier
High Quality 99% Yohimbine hydrochloride 65-19-0 GMP manufacturer
Cas No: 65-19-0
USD $ 0.1-0.1 / Gram 1 Gram 100 Metric Ton/Year Xi'an Xszo Chem Co., Ltd. Contact Supplier

65-19-0 Usage

Uses

alpha adrenergic blocker, mydriatic, antidepressant

Mechanism of action

Yohimbine hydrochloride is a pre-synaptic alpha 2-adrenergic blocking agent. The exact mechanism for its use in impotence has not been fully elucidated. However, yohimbine may exert its beneficial effect on erectile ability through blockade of central alpha 2-adrenergic receptors producing an increase in sympathetic drive secondary to an increase in norepinephrine release and in firing rate of cells in the brain noradrenergic nuclei.Yohimbine-mediated norepinephrine release at the level of the corporeal tissues may also be involved. In addition, beneficial effects may involve other neurotransmitters such as dopamine and serotonin and cholinergic receptors.

Pharmacokinetics

Yohimbine hydrochloride—an α2-adrenoceptor antagonist that is approved for treatment of erectile dysfunction—may increase BP.1,2,In normal volunteers and in patients with panic disorders, oral administration at doses used clinically may slightly increase BP.1 However, in hypertensive patients oral yohimbine was reported to induce a significant increase in mean arterial pressure.The magnitude of the pressor response was related to baseline norepinephrine levels and to the yohimbine-induced increment in plasma norepinephrine levels.Thus yohimbine increases BP by stimulation of the sympathetic nervous outflow, and the drug should be administered with caution to patients with evidence for increased basal sympathetic outflow or those undergoing concurrent treatment with tricyclic antidepressants or other drugs that interfere with neuronal uptake or metabolism of norepinephrine.

Uses

a2-adrenergic antagonist, used for erectile dysfunction

Uses

Erectile dysfunction & Mydriatic agent

Overview

Yohimbine hydrochloride is an α2-adrenergic receptor antagonist and increases the firing rate of the locus coeruleus with a resultant increase in sympathetic outflow (Redmond, 1987). Oral and intravenous yohimbine causes an increase in MHPG and blood pressure in healthy human subjects (Charney et al., 1982d; Goldberg et al., 1986). Depressed patients demonstrate an increased cortisol and blood pressure response to intravenous yohimbine compared with healthy subjects, while plasma MHPG is not significantly different between the two groups of subjects (Heninger et al., 1988). The effects of acute or chronic antidepressant treatments on the neuroendocrine or behavioural responses to yohimbine in depressed patients have not been studied.

Uses

Pharmacological probe for the study of a2-adrenoceptor.

Side effects

Yohimbine hydrochloride has been associated with high blood pressure, increased heart rate, headache, anxiety, dizziness, nausea, vomiting, tremors, and sleeplessness. It can be dangerous if taken in large doses or for long periods of time. It should not be taken in combination with monoamine oxidase (MAO) inhibitors, as effects may be additive. Yohimbe should be used with caution when taken with medicines for high blood pressure, tricyclic antidepressants, or phenothiazines. People with kidney problems and people with psychiatric conditions should not use yohimbe. Women who are pregnant or breastfeeding should not take yohimbe. The Journal of Medical Toxicology reports an instance of refractory priapism associated with ingestion of yohimbe extract, and there are other scattered reports of adverse reactions. However, may studies report it to be generally well tolerated.

Uses

vasodilator, neuromodulator

Uses

An α2-adrenoceptor antagonist

Veterinary Drugs and Treatments

Yohimbine is indicated to reverse the effects of xylazine in dogs, but it is being used clinically in several other species as well. Yohimbine may be efficacious in reversing some of the toxic effects associated with other agents (e.g., amitraz) and can be used prophylactically before amitraz dips.

Other actions

Yohimbine exerts a stimulant effect on mood and may increase blood pressure at higher doses. Yohimbine may also have mild antidiuretic action, possibly due to release of antidiuretic hormone.

Chemical Properties

Yohimbine hydrochloride is white to slightly yellow powder

Uses

Indole alkaloid with α2-adrenergic blocking activity. Mydriatic. Used in the treatment of neurological disorders.
InChI:InChI=1/C21H26N2O3/c1-26-21(25)19-15-10-17-20-14(13-4-2-3-5-16(13)22-20)8-9-23(17)11-12(15)6-7-18(19)24/h2-5,12,15,17-19,22,24H,6-11H2,1H3/p+1/t12-,15-,17-,18-,19+/m0/s1

65-19-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name Yohimbine hydrochloride

1.2 Other means of identification

Product number -
Other names Yohimban-16-carboxylic acid, 17-hydroxy-, methyl ester, monohydrochloride, (16α,17α)-

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:65-19-0 SDS

65-19-0Synthetic route

yohimbine
65-19-0

yohimbine

2α,7α-dihydroyohimbine
142696-96-6

2α,7α-dihydroyohimbine

Conditions
ConditionsYield
With sodium cyanoborohydride In trifluoroacetic acid100%
With sodium cyanoborohydride In trifluoroacetic acid at 20℃; for 3h;100%
yohimbine
65-19-0

yohimbine

1-hydroxyyohimbine
366456-76-0

1-hydroxyyohimbine

Conditions
ConditionsYield
Stage #1: yohimbine With sodium cyanoborohydride In trifluoroacetic acid at 20℃; for 3h;
Stage #2: With sodium tungstate; dihydrogen peroxide In methanol; water at 0℃; for 1h; Further stages.;
86%
Multi-step reaction with 2 steps
1: 100 percent / NaBH3CN / trifluoroacetic acid
2: 86 percent / Na2WO4*2H2O; 30 percent H2O2
View Scheme
yohimbine
65-19-0

yohimbine

A

10-hydroxy-yohimbine
41928-02-3

10-hydroxy-yohimbine

B

11-hydroxy-yohimbine

11-hydroxy-yohimbine

C

9-Hydroxyyohimbine

9-Hydroxyyohimbine

D

12-Hydroxyyohimbine

12-Hydroxyyohimbine

Conditions
ConditionsYield
With sodium persulfate; hydrogen fluoride; antimony pentafluoride at -35℃; for 1h;A 32 % Chromat.
B 23 % Chromat.
C 11 % Chromat.
D 3 % Chromat.
yohimbine
65-19-0

yohimbine

1-propargyloxyyohimbine

1-propargyloxyyohimbine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: NaBH3CN / trifluoroacetic acid / 3 h / 20 °C
1.2: 86 percent / Na2WO4*2H2O; H2O2 / H2O; methanol / 1 h / 0 °C
2.1: 99 percent / K2CO3 / dimethylformamide / 0.5 h / 20 °C
View Scheme
yohimbine
65-19-0

yohimbine

1-isopropyloxyyohimbine

1-isopropyloxyyohimbine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: NaBH3CN / trifluoroacetic acid / 3 h / 20 °C
1.2: 86 percent / Na2WO4*2H2O; H2O2 / H2O; methanol / 1 h / 0 °C
2.1: Cs2CO3 / methanol / 0.33 h / 20 °C
2.2: 99 percent / dimethylformamide / 1 h / 20 °C
View Scheme
yohimbine
65-19-0

yohimbine

(dl)-1-(1-methoxycarbonyl)ethoxyyohimbine

(dl)-1-(1-methoxycarbonyl)ethoxyyohimbine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: NaBH3CN / trifluoroacetic acid / 3 h / 20 °C
1.2: 86 percent / Na2WO4*2H2O; H2O2 / H2O; methanol / 1 h / 0 °C
2.1: Cs2CO3 / methanol / 0.33 h / 20 °C
2.2: 99 percent / dimethylformamide / 1 h / 20 °C
View Scheme
yohimbine
65-19-0

yohimbine

1-cyclohexyloxyyohimbine

1-cyclohexyloxyyohimbine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: NaBH3CN / trifluoroacetic acid / 3 h / 20 °C
1.2: 86 percent / Na2WO4*2H2O; H2O2 / H2O; methanol / 1 h / 0 °C
2.1: Cs2CO3 / methanol / 0.33 h / 20 °C
2.2: 11 percent / dimethylformamide / 1 h / 20 °C
View Scheme
yohimbine
65-19-0

yohimbine

Na-methoxyyohimbine
142756-69-2

Na-methoxyyohimbine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: NaBH3CN / trifluoroacetic acid / 3 h / 20 °C
1.2: 86 percent / Na2WO4*2H2O; H2O2 / H2O; methanol / 1 h / 0 °C
2.1: 77 percent / methanol; diethyl ether / 1 h / 0 °C
View Scheme
Multi-step reaction with 3 steps
1: 100 percent / NaBH3CN / trifluoroacetic acid
2: 86 percent / Na2WO4*2H2O; 30 percent H2O2
3: 77 percent / methanol
View Scheme
yohimbine
65-19-0

yohimbine

1-allyloxyyohimbine

1-allyloxyyohimbine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: NaBH3CN / trifluoroacetic acid / 3 h / 20 °C
1.2: 86 percent / Na2WO4*2H2O; H2O2 / H2O; methanol / 1 h / 0 °C
2.1: 99 percent / K2CO3 / dimethylformamide / 0.5 h / 20 °C
View Scheme
Multi-step reaction with 3 steps
1: 100 percent / NaBH3CN / trifluoroacetic acid
2: 86 percent / Na2WO4*2H2O; 30 percent H2O2
3: 93 percent / K2CO3 / dimethylformamide
View Scheme
yohimbine
65-19-0

yohimbine

1-n-butyloxyyohimbine

1-n-butyloxyyohimbine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: NaBH3CN / trifluoroacetic acid / 3 h / 20 °C
1.2: 86 percent / Na2WO4*2H2O; H2O2 / H2O; methanol / 1 h / 0 °C
2.1: 93 percent / K2CO3 / dimethylformamide / 0.5 h / 20 °C
View Scheme
Multi-step reaction with 3 steps
1: 100 percent / NaBH3CN / trifluoroacetic acid
2: 86 percent / Na2WO4*2H2O; 30 percent H2O2
3: 99 percent / K2CO3 / dimethylformamide
View Scheme
yohimbine
65-19-0

yohimbine

1-(p-nitrobenzyloxy)yohimbine

1-(p-nitrobenzyloxy)yohimbine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: NaBH3CN / trifluoroacetic acid / 3 h / 20 °C
1.2: 86 percent / Na2WO4*2H2O; H2O2 / H2O; methanol / 1 h / 0 °C
2.1: 90 percent / K2CO3 / dimethylformamide / 0.5 h / 20 °C
View Scheme
Multi-step reaction with 3 steps
1: 100 percent / NaBH3CN / trifluoroacetic acid
2: 86 percent / Na2WO4*2H2O; 30 percent H2O2
3: 90 percent / K2CO3 / dimethylformamide
View Scheme
yohimbine
65-19-0

yohimbine

yohimbine pseudoindoxyl A

yohimbine pseudoindoxyl A

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 100 percent / NaBH3CN / trifluoroacetic acid
2: 86 percent / Na2WO4*2H2O; 30 percent H2O2
3: 71 percent / NaOAc / 1 h / 65 °C
4: KOH / methanol / 20 °C
5: aq. NaOH / methanol / Heating
View Scheme
Multi-step reaction with 5 steps
1: 100 percent / NaBH3CN / trifluoroacetic acid
2: 86 percent / Na2WO4*2H2O; 30 percent H2O2
3: 9 percent / 48 h / 65 °C
4: KOH / methanol / 20 °C
5: aq. NaOH / methanol / Heating
View Scheme
yohimbine
65-19-0

yohimbine

(+)-7α-acetoxy-7H-yohimbine
94992-43-5

(+)-7α-acetoxy-7H-yohimbine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 100 percent / NaBH3CN / trifluoroacetic acid
2: 86 percent / Na2WO4*2H2O; 30 percent H2O2
3: 71 percent / NaOAc / 1 h / 65 °C
View Scheme
Multi-step reaction with 3 steps
1: 100 percent / NaBH3CN / trifluoroacetic acid
2: 86 percent / Na2WO4*2H2O; 30 percent H2O2
3: 9 percent / 48 h / 65 °C
View Scheme
yohimbine
65-19-0

yohimbine

(1R,2S,4aR,8aS,13bS,14aS)-2,8a-Dihydroxy-1,2,3,4,4a,5,7,8,8a,13b,14,14a-dodecahydro-indolo[2',3':3,4]pyrido[1,2-b]isoquinoline-1-carboxylic acid methyl ester
2288-52-0

(1R,2S,4aR,8aS,13bS,14aS)-2,8a-Dihydroxy-1,2,3,4,4a,5,7,8,8a,13b,14,14a-dodecahydro-indolo[2',3':3,4]pyrido[1,2-b]isoquinoline-1-carboxylic acid methyl ester

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 100 percent / NaBH3CN / trifluoroacetic acid
2: 86 percent / Na2WO4*2H2O; 30 percent H2O2
3: 71 percent / NaOAc / 1 h / 65 °C
4: KOH / methanol / 20 °C
View Scheme
Multi-step reaction with 4 steps
1: 100 percent / NaBH3CN / trifluoroacetic acid
2: 86 percent / Na2WO4*2H2O; 30 percent H2O2
3: 9 percent / 48 h / 65 °C
4: KOH / methanol / 20 °C
View Scheme
yohimbine
65-19-0

yohimbine

17-O-acetyl-7α-hydroxyyohimbine

17-O-acetyl-7α-hydroxyyohimbine

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 100 percent / NaBH3CN / trifluoroacetic acid
2: 86 percent / Na2WO4*2H2O; 30 percent H2O2
3: 71 percent / NaOAc / 1 h / 65 °C
4: 62 percent / 6 h / 65 °C
5: 96 percent / NaHCO3 / methanol / 13 h / 24 °C
View Scheme
Multi-step reaction with 4 steps
1: 100 percent / NaBH3CN / trifluoroacetic acid
2: 86 percent / Na2WO4*2H2O; 30 percent H2O2
3: 8 percent / NaOAc / 1 h / 65 °C
4: 96 percent / NaHCO3 / methanol / 13 h / 24 °C
View Scheme
Multi-step reaction with 5 steps
1: 100 percent / NaBH3CN / trifluoroacetic acid
2: 86 percent / Na2WO4*2H2O; 30 percent H2O2
3: 9 percent / 48 h / 65 °C
4: 62 percent / 6 h / 65 °C
5: 96 percent / NaHCO3 / methanol / 13 h / 24 °C
View Scheme
Multi-step reaction with 4 steps
1: 100 percent / NaBH3CN / trifluoroacetic acid
2: 86 percent / Na2WO4*2H2O; 30 percent H2O2
3: 44 percent / 48 h / 65 °C
4: 96 percent / NaHCO3 / methanol / 13 h / 24 °C
View Scheme
Multi-step reaction with 3 steps
1: 100 percent / NaBH3CN / trifluoroacetic acid
2: 86 percent / Na2WO4*2H2O; 30 percent H2O2
3: 12 percent / NaOAc / 6 h / 65 °C
View Scheme
yohimbine
65-19-0

yohimbine

7α,17α-diacetoxy-7H-yohimbine
364777-89-9

7α,17α-diacetoxy-7H-yohimbine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 100 percent / NaBH3CN / trifluoroacetic acid
2: 86 percent / Na2WO4*2H2O; 30 percent H2O2
3: 71 percent / NaOAc / 1 h / 65 °C
4: 62 percent / 6 h / 65 °C
View Scheme
Multi-step reaction with 3 steps
1: 100 percent / NaBH3CN / trifluoroacetic acid
2: 86 percent / Na2WO4*2H2O; 30 percent H2O2
3: 8 percent / NaOAc / 1 h / 65 °C
View Scheme
Multi-step reaction with 4 steps
1: 100 percent / NaBH3CN / trifluoroacetic acid
2: 86 percent / Na2WO4*2H2O; 30 percent H2O2
3: 9 percent / 48 h / 65 °C
4: 62 percent / 6 h / 65 °C
View Scheme
Multi-step reaction with 3 steps
1: 100 percent / NaBH3CN / trifluoroacetic acid
2: 86 percent / Na2WO4*2H2O; 30 percent H2O2
3: 44 percent / 48 h / 65 °C
View Scheme
yohimbine
65-19-0

yohimbine

C25H30N2O6

C25H30N2O6

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 100 percent / NaBH3CN / trifluoroacetic acid
2: 86 percent / Na2WO4*2H2O; 30 percent H2O2
3: 16 percent / 48 h / 65 °C
View Scheme
Multi-step reaction with 3 steps
1: 100 percent / NaBH3CN / trifluoroacetic acid
2: 86 percent / Na2WO4*2H2O; 30 percent H2O2
3: 12 percent / NaOAc / 6 h / 65 °C
View Scheme
yohimbine
65-19-0

yohimbine

yohimbohydrazide hydrate

yohimbohydrazide hydrate

Conditions
ConditionsYield
With hydrazine hydrate In ethanol
yohimbine
65-19-0

yohimbine

yohimbinic acid
522-87-2

yohimbinic acid

Conditions
ConditionsYield
With sodium hydroxide In methanol; water

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