65-31-6 Usage
Uses
Different sources of media describe the Uses of 65-31-6 differently. You can refer to the following data:
1. nicotinyl acetylchloline receptor agonist, ectoparasiticide
2. cathartic, laxative
General Description
Potent agonist of the nicotinic acetylcholine receptor. Stimulates autonomic ganglia and skeletal muscle neuromuscular junctions.
Biological Activity
Nicotinic acetylcholine receptor (nAChR) agonist (K i values are 1, > 1000, 4000 and 7130 nM at α 4 β 2, α 1 β 1 δ γ , rat α 7 and human α 7 respectively). Exhibits vasoconstrictive, hypertensive and prothrombotic activity in vivo .
Biochem/physiol Actions
Product does not compete with ATP.
Safety Profile
Poison by ingestion,
intravenous, intraperitoneal, and
subcutaneous routes. An experimental
teratogen. Experimental reproductive
effects. When heated to decomposition it
emits toxic fumes of NOx and CO. See also
NICOTINE.
Check Digit Verification of cas no
The CAS Registry Mumber 65-31-6 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 6 and 5 respectively; the second part has 2 digits, 3 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 65-31:
(4*6)+(3*5)+(2*3)+(1*1)=46
46 % 10 = 6
So 65-31-6 is a valid CAS Registry Number.
InChI:InChI=1/C10H14N2.C4H6O6/c1-12-7-3-5-10(12)9-4-2-6-11-8-9;5-1(3(7)8)2(6)4(9)10/h2,4,6,8,10H,3,5,7H2,1H3;1-2,5-6H,(H,7,8)(H,9,10)/t10-;/m0./s1
65-31-6Relevant articles and documents
Disposition kinetics of nicotine and cotinine enantiomers in rabbits and beagle dogs
Jacob III,Benowitz,Copeland,Risner,Cone
, p. 396 - 400 (2007/10/02)
The disposition kinetics of nicotine and cotinine enantiomers was determined in rabbits. The clearance of (R)-nicotine was similar to that of (S)-nicotine, but clearance of (R)-cotinine was twice that of (S)-cotinine. Fractional conversions of both enantiomers of nicotine to cotinine were ~50%. These results suggest that in rabbits the biotransformation pathways of cotinine, but not nicotine, are influenced by stereochemistry. The disposition kinetics of nicotine enantiomers in beagle dogs was also studied. In dogs, the clearance of (R)-nicotine was slightly greater than the clearance of (S)-nicotine. Methods for the synthesis of (R)-nicotine and (R)-cotinine of high enantiomeric purity and a gas chromatographic method for determination of nicotine enantiomeric purity are described.