65006-89-5Relevant articles and documents
Inhibition of the pore-forming protein perforin by a series of aryl-substituted isobenzofuran-1(3H)-ones
Spicer, Julie A.,Huttunen, Kristiina M.,Miller, Christian K.,Denny, William A.,Ciccone, Annette,Browne, Kylie A.,Trapani, Joseph A.
experimental part, p. 1319 - 1336 (2012/03/26)
An aryl-substituted isobenzofuran-1(3H)-one lead compound was identified from a high throughput screen designed to find inhibitors of the lymphocyte pore-forming protein perforin. A series of analogs were then designed and prepared, exploring structure-ac
Linear self-eliminating oligomers
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, (2009/12/07)
The present invention relates to a linear self-eliminating oligomer comprising one or more cleavable triggers, linker units, effector units and a carrier, and a pharmaceutical composition comprising said oligomer.