65006-89-5Relevant academic research and scientific papers
Inhibition of the pore-forming protein perforin by a series of aryl-substituted isobenzofuran-1(3H)-ones
Spicer, Julie A.,Huttunen, Kristiina M.,Miller, Christian K.,Denny, William A.,Ciccone, Annette,Browne, Kylie A.,Trapani, Joseph A.
experimental part, p. 1319 - 1336 (2012/03/26)
An aryl-substituted isobenzofuran-1(3H)-one lead compound was identified from a high throughput screen designed to find inhibitors of the lymphocyte pore-forming protein perforin. A series of analogs were then designed and prepared, exploring structure-ac
COMPOUNDS, PREPARATIONS AND USES THEREOF
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Page/Page column 92-93, (2011/07/09)
The present invention provides novel compounds of the Formula (I), pharmaceutical compositions comprising such compounds and methods for using such compounds as agents or drugs for inhibiting perforin activity and for treating a subject at risk of or susc
Linear self-eliminating oligomers
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, (2009/12/07)
The present invention relates to a linear self-eliminating oligomer comprising one or more cleavable triggers, linker units, effector units and a carrier, and a pharmaceutical composition comprising said oligomer.
WATER-SOLUBLE TRIAZOLE FUNGICIDE
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Page/Page column 112-113, (2010/02/07)
A triazole compound of the general formula (I) or a pharmacologically acceptable salt thereof: [wherein,X represents a group of formula X-OH which has antifungal activity,L represents a -(adjacently substituted C6-C10 aryl)-CH2-group and the like, andR represents a -P(=O) (OH)2 group and the like.
