333333-34-9

Usage

Uses

Used in Fragrance and Flavoring Industry:
1,3-dihydro-1-oxo-5-Isobenzofurancarboxaldehyde is used as a key ingredient in the production of fragrances and flavorings due to its distinctive floral odor, enhancing the sensory experience of various consumer products.
Used in Pharmaceutical Industry:
As an intermediate, 1,3-dihydro-1-oxo-5-Isobenzofurancarboxaldehyde plays a crucial role in the manufacturing process of pharmaceuticals, contributing to the development of new drugs and medicines.
Used in Agrochemical Industry:
Similarly, in the agrochemical sector, 1,3-dihydro-1-oxo-5-Isobenzofurancarboxaldehyde serves as an intermediate in the synthesis of various agrochemicals, aiding in the production of effective crop protection agents and other agricultural products.

Upstream product

• 7732-18-5 water 
• 876156-35-3 5-ethenyl-2-benzofuran-1(3H)-one 
• 64169-34-2 5-bromophthalide 
• 20461-86-3 2,2-diethoxy acetic acid 
• 4792-29-4 5-carboxyphtalide 
• 227954-90-7 (1-oxo-1,3-dihydroisobenzofuran-5-yl)carbonyl chloride 
• 65006-89-5 5-(hydroxymethyl)isobenzofuran-1(3H)-one 
• 611-01-8 2,4-dimethyl-benzoic acid 
• 89-74-7 2,4-dimethylacetophenone. 
• 21900-42-5 2,4-dimethylbenzoyl chloride 
• 108-38-3 m-xylene 

Downstream Products

• 23405-34-7 hydroxymethyl-terephthalic acid 

Relevant academic research and scientific papers

SUBSTITUTED BICYCLIC HETEROCYCLIC COMPOUNDS

Disclosed are compounds of Formula (I), or a salt thereof, wherein: X is CR4 or N; Y is CR4 or N, provided that Y is N only if X is N; R1 is Formulae (A) or (B); each W is independently NR1b or O; Z is a bond or CHR1d; and R1, R2, R3, R4, L1, R1a, R1b, R1c, and n are defined herein. Also disclosed are methods of using such compounds as inhibitors of ROMK, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating cardiovascular diseases.

Visible-Light-Promoted Nickel- and Organic-Dye-Cocatalyzed Formylation Reaction of Aryl Halides and Triflates and Vinyl Bromides with Diethoxyacetic Acid as a Formyl Equivalent

A simple formylation reaction of aryl halides, aryl triflates, and vinyl bromides under synergistic nickel- and organic-dye-mediated photoredox catalysis is reported. Distinct from widely used palladium-catalyzed formylation processes, this reaction proceeds by a two-step mechanistic sequence involving initial in situ generation of the diethoxymethyl radical from diethoxyacetic acid by a 4CzIPN-mediated photoredox reaction. The formyl-radical equivalent then undergoes nickel-catalyzed substitution reactions with aryl halides and triflates and vinyl bromides to form the corresponding aldehyde products. Significantly, besides aryl bromides, less reactive aryl chlorides and triflates and vinyl halides serve as effective substrates for this process. Since the mild conditions involved in this reaction tolerate a plethora of functional groups, the process can be applied to the efficient preparation of diverse aromatic aldehydes.

Inhibition of the pore-forming protein perforin by a series of aryl-substituted isobenzofuran-1(3H)-ones

An aryl-substituted isobenzofuran-1(3H)-one lead compound was identified from a high throughput screen designed to find inhibitors of the lymphocyte pore-forming protein perforin. A series of analogs were then designed and prepared, exploring structure-ac

COMPOUNDS, PREPARATIONS AND USES THEREOF

The present invention provides novel compounds of the Formula (I), pharmaceutical compositions comprising such compounds and methods for using such compounds as agents or drugs for inhibiting perforin activity and for treating a subject at risk of or susc

WATER-SOLUBLE TRIAZOLE FUNGICIDE

A triazole compound of the general formula (I) or a pharmacologically acceptable salt thereof: [wherein,X represents a group of formula X-OH which has antifungal activity,L represents a -(adjacently substituted C6-C10 aryl)-CH2-group and the like, andR represents a -P(=O) (OH)2 group and the like.

Process for the preparation of 5-subtituted isobenzofurans

There is described a process for the preparation of citalopram and of its pharmaceutically acceptable salts, which comprises treating a 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofurancarbaldoxime, O-substituted preferably with a diphenylmethyl or triphenylmethyl group, with formic-acetic anhydride. Furthermore, the total synthesis of citalopram, as free base or in form of its pharmaceutically acceptable salt, starting from 5-formylphthalide is described.

Process for the preparation of 5-Formylphthalide

There is described a process for the preparation of 5-formylphthalide by hydrogenation of a halide of 5-carboxyphthalide, dissolved in a dipolar aprotic solvent, in the presence of a catalyst.Furthermore, the use of 5-formylphthalide in the preparation of citalopram is described.