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65040-36-0

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65040-36-0 Usage

Chemical structure

1-(5-Bromo-1H-indol-3-yl)-2-chloro-ethanone is a derivative of indole, a heterocyclic organic compound, with a bromo-substituted indole ring attached to a 2-chloro-ethanone group.

Application

It is commonly used in the field of organic synthesis and medicinal chemistry as a building block for the creation of various pharmaceuticals and biologically active molecules.

Safety precautions

This compound should be handled with care and proper safety measures should be followed when working with it due to its potential health hazards.

Functional groups

The compound contains a bromo-substituted indole ring and a 2-chloro-ethanone group.

Physical properties

The specific physical properties of 1-(5-Bromo-1H-indol-3-yl)-2-chloro-ethanone are not provided in the material.

Chemical properties

The specific chemical properties of 1-(5-Bromo-1H-indol-3-yl)-2-chloro-ethanone are not provided in the material.

Reactivity

The compound is likely to be reactive due to the presence of the bromo-substituted indole ring and the 2-chloro-ethanone group, but specific reactivity information is not provided in the material.

Stability

The stability of 1-(5-Bromo-1H-indol-3-yl)-2-chloro-ethanone is not mentioned in the material.

Solubility

The solubility of 1-(5-Bromo-1H-indol-3-yl)-2-chloro-ethanone is not provided in the material.

Purity

The purity of 1-(5-Bromo-1H-indol-3-yl)-2-chloro-ethanone is not mentioned in the material.

Check Digit Verification of cas no

The CAS Registry Mumber 65040-36-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,5,0,4 and 0 respectively; the second part has 2 digits, 3 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 65040-36:
(7*6)+(6*5)+(5*0)+(4*4)+(3*0)+(2*3)+(1*6)=100
100 % 10 = 0
So 65040-36-0 is a valid CAS Registry Number.

65040-36-0Downstream Products

65040-36-0Relevant articles and documents

Meridianin D Analogues Display Antibiofilm Activity against MRSA and Increase Colistin Efficacy in Gram-Negative Bacteria

Huggins, William M.,Barker, William T.,Baker, James T.,Hahn, Nicholas A.,Melander, Roberta J.,Melander, Christian

, p. 702 - 707 (2018/06/04)

In the last 30 years, development of new classes of antibiotics has slowed, increasing the necessity for new options to treat multidrug resistant bacterial infections. Development of antibiotic adjuvants that increase the effectiveness of currently available antibiotics is a promising alternative approach to classical antibiotic development. Reports of the ability of the natural product meridianin D to modulate bacterial behavior have been rare. Herein, we describe the ability of meridianin D to inhibit biofilm formation of methicillin-resistant Staphylococcus aureus (MRSA) and to increase the potency of colistin against colistin-resistant and sensitive Gram-negative bacteria. Analogues were identified that are capable of inhibiting and dispersing MRSA biofilms and lowering the colistin MIC to below the CLSI breakpoint against Acinetobacter baumannii, Klebsiella pneumoniae, and Escherichia coli.

Development of 3-substituted-1H-indole derivatives as NR2B/NMDA receptor antagonists

Gitto, Rosaria,Luca, Laura De,Ferro, Stefania,Citraro, Rita,Sarro, Giovambattista De,Costa, Lara,Ciranna, Lucia,Chimirri, Alba

scheme or table, p. 1640 - 1647 (2009/09/08)

A combined ligand-based and structure-based approach has previously allowed us to identify NR2B/NMDA receptor antagonists containing indole scaffold. In order to further explore the main structure activity relationships of this class of derivatives we herein report the design, synthesis and biological evaluation of new analogues. Some derivatives demonstrated to produce significant anticonvulsant properties and NMDA antagonism. The most active of them (3d) showed NR2B binding affinity equipotent to that of ifenprodil. These results were also corroborated by computational studies.

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