65051-24-3

Usage

Uses

Used in Organic Synthesis:
(4-FLUOROBENZYL)THIO]ACETIC ACID is used as a building block in organic synthesis for the development of pharmaceuticals and other biologically active compounds.
Used in Drug Discovery Research:
(4-FLUOROBENZYL)THIO]ACETIC ACID is used as a starting material in drug discovery research to create new pharmaceuticals and biologically active compounds.
Used in Medicinal Chemistry:
(4-FLUOROBENZYL)THIO]ACETIC ACID is used in medicinal chemistry for its structural and functional properties, which may contribute to the development of new therapeutic agents.
Used in Chemical Biology:
(4-FLUOROBENZYL)THIO]ACETIC ACID is used in chemical biology to study the interactions between small molecules and biological systems, potentially leading to the discovery of new drugs and therapeutic targets.

InChI:InChI=1/C9H9FO2S/c10-8-3-1-7(2-4-8)5-13-6-9(11)12/h1-4H,5-6H2,(H,11,12)

Upstream product

• 79-11-8 chloroacetic acid 
• 352-11-4 1-chloromethyl-4-fluorobenzene 
• 68-11-1 mercaptoacetic acid 
• 3926-62-3 sodium monochloroacetic acid 

Downstream Products

• 65051-26-5 2-(4-fluorobenzylmercapto)-acetohydroxamic acid 
• 222639-41-0 2-[(4-fluorobenzyl)sulfonyl]acetic acid 
• 65051-27-6 Fluorbenzylsulfinylacetohydroxamsaeure 

Relevant academic research and scientific papers

Design, synthesis and preliminary biological evaluation of benzylsulfone coumarin derivatives as anti-cancer agents

In this work, a series of benzylsulfone coumarin derivatives 5a-5o were synthesized and characterized. Kinase inhibitory activity assay indicated that most of the compounds showed considerable activity against PI3K. Anti-tumor activity studies of the active compounds were also carried out in vitro on the Hela, HepG2, H1299, HCT-116, and MCF-7 tumor cell lines by MTS assay. The structure-activity relationships (SARs) of these compounds were analyzed in detail. Compound 5h exhibited the most potent activities against the mentioned cell lines with IC50 values ranging from 18.12 to 32.60 μM, followed by 5m with IC50 values of 29.30-42.14 μM. Furthermore, 5h and 5m clearly retarded the migration of Hela cells in vitro. Next, an in silico molecular docking study was conducted to evaluate the binding models of 5h and 5m towards PI3Kαand PI3Kβ. Collectively, the above findings suggested that compounds 5h and 5m might be promising PI3K inhibitors deserving further investigation for cancer treatment.

Phenylamidine derivatives

A compound having the general formula: STR1 wherein Ar is an aryl group (especially an α-naphthyl, β-naphthyl or phenyl group) which may be substituted by one or more C1-4 alkyl, C1-4 alkoxy, methylenedioxy halogen, CF3, NH2 or NO2 groups; A is a --CH2 --, --CHOH--, --CH2 O--, --CH2 S--, --CH2 NH--, --OCH2 --, --SCH2 --, --NH--, --NHCOCH2 --, --CH2 NHCH2 -- or --NHCH2 -- group; Y is O or NH; and B is a single bond and, when A is --CH2 --S, may be a --CH2 --, or --CH(CH3)-- group; and their acid addition salts when Y is NH and their metal salts when Y is O. The compounds and their salts have therapeutic utility in treatment of neuropsychic ailments.

Acetohydroxamic acids

The invention provides new acetohydroxamic acid derivatives, having interesting properties on the central nervous system, of the formula: R1 R2 R3 C-CO-NHOH, in which R2 and R3 are each hydrogen or C1-6 alkyl, and R1 is C1-6 alkyl Z1 Z2 N (where Z1 and Z2 are each phenyl, substituted phenyl, or cycloalkyl), substituted hydantoinyl, benzhydroxylcarboxamido, Z3 CH2 -- (where Z3 = optionally substituted aryl), Z4 -A- (where Z4 is optionally substituted phenyl or naphthyl, and A is --NH--, --N(C1-4 alkyl)--, --N(C5-6 cycloalkyl)--, --NHCO--, --N(C1-4 alkyl)CO--, --N(C5-6 cycloalkyl)CO--, --CONH--, --CON(C1-4 alkyl)--, --CON(C5-6 cycloalkyl)--, --NHCONH--, --N(C5 H6)CONH--, or --N(substituted phenyl)CONH--, optionally substituted benzimidazolyl, or an optionally substituted tricyclic radical, and their metal and acid addition salts.