65062-61-5 Usage
Uses
Used in Biochemical Research:
3-Thymidylic acid, 5-O-(bis(4-methoxyphenyl)phenylmethyl)-, mono(4-chlorophenyl) ester, compd. with N,N-diethylethanamine (1:1) is used as a research tool for studying the synthesis of DNA and the role of nucleoside monophosphates in genetic processes. Its unique structure allows for the investigation of molecular interactions and mechanisms in DNA replication and repair.
Used in Pharmaceutical Development:
In the pharmaceutical industry, 3-Thymidylic acid, 5-O-(bis(4-methoxyphenyl)phenylmethyl)-, mono(4-chlorophenyl) ester, compd. with N,N-diethylethanamine (1:1) may be utilized as a precursor or intermediate in the synthesis of drugs targeting DNA-related diseases or conditions. Its potential applications could include the development of antiviral agents, anticancer therapies, or treatments for genetic disorders, leveraging its involvement in DNA synthesis and the unique properties of its ester and amine components.
Used in Biotechnology Applications:
3-Thymidylic acid, 5-O-(bis(4-methoxyphenyl)phenylmethyl)-, mono(4-chlorophenyl) ester, compd. with N,N-diethylethanamine (1:1) may also find use in biotechnological applications, such as the development of novel nucleic acid-based therapies or the creation of advanced biosensors. Its chemical properties could be harnessed to improve the efficiency, specificity, or stability of these technologies.
Check Digit Verification of cas no
The CAS Registry Mumber 65062-61-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,5,0,6 and 2 respectively; the second part has 2 digits, 6 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 65062-61:
(7*6)+(6*5)+(5*0)+(4*6)+(3*2)+(2*6)+(1*1)=115
115 % 10 = 5
So 65062-61-5 is a valid CAS Registry Number.
65062-61-5Relevant academic research and scientific papers
31P NMR Study of the Mechanism of Activation and Coupling Reactions in the Synthesis of Oligodeoxyribonucleotides by the Phosphotriester Method
Chandrasegaran, Srinivasan,Murakami, Akira,Kan, Lou-sing
, p. 4951 - 4957 (2007/10/02)
The phosphotriester method provides a rapid and convenient procedure for synthesizing oligonucleotides.The mechanism has been revealed and intermediates have been identified by 31P NMR methodology.It was found that reaction of a 5'-protected nucleoside 3'-(p-chlorophenyl phosphate) with mesitylenesulfonyl chloride (MSCl) or 1-(mesitylyl-2-sulfonyl)-3-nitro-1,2,4-triazole (MSNT) in anhydrous pyridine yields only two products within 5 min, the sulfonic acid-phosphate mixed anhydride 2 and the (3'-3') symmetrical pyrophosphate tetraester 3 which can be isolated as a mixture.Reaction of 2 and 3 with 3'-O-acetylthymidine yields the phosphotriester dimer NpTOAc.The reaction rate and yield of dimers are closely dependent on the presence of catalysts.The reaction finished within minutes when tetrazole or 3-nitro-1,2,4-triazole was used.On the contrary, the reaction completed in hours when imidazole or 1,2,4-triazole was used as catalysts.The possible mechanisms are explored and discussed in detail.
