65062-61-5

Basic information

• Product Name: 3-Thymidylic acid, 5-O-(bis(4-methoxyphenyl)phenylmethyl)-, mono(4-chlorophenyl) ester, compd. with N,N-diethylethanamine (1:1)
• CAS NO: 65062-61-5
• Molecular Weight: 836.319
• Mol File: 65062-61-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-Thymidylic acid, 5-O-(bis(4-methoxyphenyl)phenylmethyl)-, mono(4-chlorophenyl) ester, compd. with N,N-diethylethanamine (1:1)(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Thymidylic acid, 5-O-(bis(4-methoxyphenyl)phenylmethyl)-, mono(4-chlorophenyl) ester, compd. with N,N-diethylethanamine (1:1)(65062-61-5)
• EPA Substance Registry System: 3-Thymidylic acid, 5-O-(bis(4-methoxyphenyl)phenylmethyl)-, mono(4-chlorophenyl) ester, compd. with N,N-diethylethanamine (1:1)(65062-61-5)

Safety Data

• Hazardous Substances Data: 65062-61-5(Hazardous Substances Data)

Usage

General Description

3-Thymidylic acid, 5-O-(bis(4-methoxyphenyl)phenylmethyl)-, mono(4-chlorophenyl) ester, compd. with N,N-diethylethanamine (1:1) is a chemical compound that is formed by combining thymidylic acid, bis(4-methoxyphenyl)phenylmethyl ester with N,N-diethylethanamine in a 1:1 ratio. Thymidylic acid is a nucleoside monophosphate that is involved in the synthesis of DNA, while the ester and amine components are organic compounds with specific chemical properties and functions. 3-Thymidylic acid, 5-O-(bis(4-methoxyphenyl)phenylmethyl)-, mono(4-chlorophenyl) ester, compd. with N,N-diethylethanamine (1:1) may have potential applications in biochemistry, pharmacology, and biotechnology, and could be used in research and industrial settings for various purposes. However, it is important to carefully consider its potential uses and safety precautions due to the presence of multiple chemical components and their potential interactions.

Upstream product

• 93403-69-1 C₇₄H₇₀Cl₂N₄O₁₉P₂ 
• 67221-57-2 5'-O-(dimethoxytrityl)thymidine 3'-(p-chlorphenylcyanoethyl phosphate) 

Downstream Products

• 93403-66-8 C₄₆H₄₆ClN₂O₁₂PS 
• 93403-69-1 C₇₄H₇₀Cl₂N₄O₁₉P₂ 
• 76859-58-0 <(MeO)2Tr>TpTOAc 
• 93403-75-9 5'-O-(dimethoxytrityl)thymidine 3'-(p-chlorophenyl phosphoro-3-nitro-1,2,4-triazolide) 
• 71459-54-6 C₅₄H₅₂ClN₄O₁₅P 
• 93403-74-8 5'-O-(dimethoxytrityl)thymidine 3'-(p-chlorophenyl phosphorotetrazolide) 
• 93403-73-7 5'-O-(dimethoxytrityl)thymidine 3'-(p-chlorophenyl phosphoro-1,2,4-triazolide) 

Relevant articles and documents

31P NMR Study of the Mechanism of Activation and Coupling Reactions in the Synthesis of Oligodeoxyribonucleotides by the Phosphotriester Method

The phosphotriester method provides a rapid and convenient procedure for synthesizing oligonucleotides.The mechanism has been revealed and intermediates have been identified by 31P NMR methodology.It was found that reaction of a 5'-protected nucleoside 3'-(p-chlorophenyl phosphate) with mesitylenesulfonyl chloride (MSCl) or 1-(mesitylyl-2-sulfonyl)-3-nitro-1,2,4-triazole (MSNT) in anhydrous pyridine yields only two products within 5 min, the sulfonic acid-phosphate mixed anhydride 2 and the (3'-3') symmetrical pyrophosphate tetraester 3 which can be isolated as a mixture.Reaction of 2 and 3 with 3'-O-acetylthymidine yields the phosphotriester dimer NpTOAc.The reaction rate and yield of dimers are closely dependent on the presence of catalysts.The reaction finished within minutes when tetrazole or 3-nitro-1,2,4-triazole was used.On the contrary, the reaction completed in hours when imidazole or 1,2,4-triazole was used as catalysts.The possible mechanisms are explored and discussed in detail.