650624-50-3

Upstream product

• 451-40-1 phenyl benzyl ketone 
• 611-94-9 4-Methoxybenzophenone 
• 103-65-1 phenylpropane 
• 16282-16-9 1,2-diphenyl-butan-1-one 
• 13139-86-1 4-methoxyphenyl magnesium bromide 

Downstream Products

• 82333-66-2 Acetic acid 4-((E)-1,2-diphenyl-but-1-enyl)-phenyl ester 
• 82333-65-1 Acetic acid 4-((Z)-1,2-diphenyl-but-1-enyl)-phenyl ester 
• 69967-79-9 ICI 77949 
• 6462-19-7 (E)-[1-(4-methoxyphenyl)but-1-ene-1,2-diyl]dibenzene 
• 6462-18-6 (Z)-(1-(4-methoxyphenyl)but-1-ene-1,2-diyl)dibenzene 

Relevant academic research and scientific papers

Easy access to secondary and tertiary alcoholsviametal-free and light mediated radical carbonyl allylation

Here we report a strategy for carbonyl addition with unactivated alkenes using an organic photocatalyst on both aldehyde and ketone substrates. This protocol grants us a good alternative to the traditional Barbier-Grignard allylation that exhibits poor functional group tolerance. With this method the stoichiometric use of metals can be avoided, high atom economy can be achieved and fewer by-products are generated.

1,1,2-Triphenylbut-1-enes: Relationship between Structure, Estradiol Receptor Affinity, and Mammary Tumor Inhibiting Properties

1,1,2-Triphenylbut-1-enes, which are substituted with acetoxy groups on one, two, or three aromatic rings in the para and/or meta positions, were synthesized.The identity of the occurring E and Z isomers were established by 1H NMR spectroscopy.A study on structure-activity relationships was carried out with regard to estradiol receptor affinity and to inhibiting effects on the growth of a postmenopausal human mammary carcinoma implanted in nude mice.The para-substituted compounds generally exhibited a higher receptor affinity and a better antitumor activity than the corresponding meta-substituted ones.The E isomers were superior to the respective Z isomers in those two properties.The tumor-inhibiting effect of the mono-and disubstituted compounds was better than that of the trisubstituted ones.Except for the trisubstituted compounds, they all showed a good correlation between estradiol receptor affinity and antitumor activity.One of the compounds was also tested on the 9,10-dimethylbenzanthracene-induced, hormone-dependent mammary carcinoma of the Spraque-Dawley rat, and the results corresponded to those obtained in the xenograft tumor.