65065-56-7Relevant academic research and scientific papers
Synthesis and biological activity of novel deoxycholic acid derivatives
Popadyuk, Irina I.,Markov, Andrey V.,Salomatina, Oksana V.,Logashenko, Evgeniya B.,Shernyukov, Andrey V.,Zenkova, Marina A.,Salakhutdinov, Nariman F.
, p. 5022 - 5034 (2015/08/03)
We report the synthesis and biological activity of new semi-synthetic derivatives of naturally occurring deoxycholic acid (DCA) bearing 2-cyano-3-oxo-1-ene, 3-oxo-1(2)-ene or 3-oxo-4(5)-ene moieties in ring A and 12-oxo or 12-oxo-9(11)-ene moieties in ring C. Bioassays using murine macrophage-like cells and tumour cells show that the presence of the 9(11)-double bond associated with the increased polarity of ring A or with isoxazole ring joined to ring A, improves the ability of the compounds to inhibit cancer cell growth.
HYDROGENATION OF 12-OXO-5β-CHOL-9(11)-ENATES ON PLATINUM
Kasal, Alexander
, p. 1839 - 1849 (2007/10/02)
Methyl 12-oxo-5β-chol-9(11)-enates with various substituents in the position 3 were prepared and the conditions were found under which hydrogenation of the supposedly resistent double bond of 9α-cholanates takes place.Under these conditions the products of deoxygenation in the position 12, and in the case of the hydrogenation of 3-oxo derivatives the products of deoxygenation in the position 3, were isolated as side-products of this reaction.The rate of the last mentioned reaction is a function of the excess of the catalyst.
