65069-53-6

Basic information

• Product Name: 1-(4-BENZYLOXYPHENYL)-2-THIOUREA
• Synonyms: 1-(4-BENZYLOXYPHENYL)-2-THIOUREA;N-[4-(BENZYLOXY)PHENYL]THIOUREA;1-[4-(Benzyloxy)phenyl]thiourea 98%;1-(Benzyloxy)-4-thioureidobenzene, 1-(Benzyloxy)-4-(carbamothioylamino)benzene;1-[4-(Benzyloxy)phenyl]thiourea98%
• CAS NO: 65069-53-6
• Molecular Formula: C₁₄H₁₄N₂OS
• Molecular Weight: 258.34
• Mol File: 65069-53-6.mol
• Article Data: 5

Chemical Properties

• Melting Point: 195-197°C
• Boiling Point: 423.2°C at 760 mmHg
• Flash Point: 209.8°C
• Appearance: /
• Density: 1.277g/cm³
• Vapor Pressure: 2.27E-07mmHg at 25°C
• Refractive Index: 1.696
• PKA: 13.43±0.70(Predicted)
• CAS DataBase Reference: 1-(4-BENZYLOXYPHENYL)-2-THIOUREA(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-BENZYLOXYPHENYL)-2-THIOUREA(65069-53-6)
• EPA Substance Registry System: 1-(4-BENZYLOXYPHENYL)-2-THIOUREA(65069-53-6)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 65069-53-6(Hazardous Substances Data)

Usage

General Description

1-(4-Benzyloxyphenyl)-2-thiourea is a synthetic organic compound with the chemical formula C14H14N2OS. Thioureas are a class of organic compounds that contain a sulfur atom attached to a carbon atom, and this particular compound is characterized by the presence of a benzyl group and an oxyphenyl group. It is commonly used as a reagent in organic synthesis and as a starting material for the preparation of various pharmaceuticals and agrochemicals. Additionally, it has been studied for its potential biological activities, including its anti-cancer and anti-inflammatory properties. 1-(4-BENZYLOXYPHENYL)-2-THIOUREA has drawn interest in the fields of medicinal chemistry and chemical biology for its potential applications in drug discovery and development.

InChI:InChI=1/C14H14N2OS/c15-14(18)16-12-6-8-13(9-7-12)17-10-11-4-2-1-3-5-11/h1-9H,10H2,(H3,15,16,18)

Upstream product

• 6373-46-2 p-benzyloxyaniline 
• 139768-71-1 4-benzyloxyphenyl isothiocyanate 
• 51388-20-6 4-benzyloxyaniline hydrochloride 

Downstream Products

• 139768-72-2 4-benzyloxyphenylcyanamide 
• 65070-11-3 N-(4-Benzyloxy-phenyl)-pyrrolidine-1-carboxamidine 
• 65069-79-6 1-(4-Benzyloxy-phenyl)-2-methyl-isothiourea; hydriodide 

Relevant articles and documents

SUBSTITUTED ARYLTHIOUREA DERIVATIVES USEFUL AS INHIBITORS OF VIRAL REPLICATION

Substituted arylthiourea compounds of Formula I, and the pharmaceutically acceptable salts of such compounds, useful as antiviral agents, are provided herein. Certain substituted arylthioureas disclosed herein are potent and/ or selective inhibitors of viral replication, particularly Hepatitis C virus replication. Pharmaceutical compositions containing one or more substituted arylthiourea compounds and one or more pharmaceutically acceptable carriers, excipients, or diluents are provided herein. Such pharmaceutical compositions may contain a substituted arylthiourea as the only active agent or may contain a combination of a substituted arylthiourea derivative and one or more other pharmaceutically active agents. Methods of treating Hepatitis C viral infections in mammals are also provided herein.

Substituted N-phenylisothioureas: Potent inhibitors of human nitric oxide synthase with neuronal isoform selectivity

S-Ethyl N-phenylisothiourea (4) has been found to be a potent inhibitor of both the human constitutive and inducible isoforms of nitric oxide synthase. A series of substituted N-phenylisothiourea analogues was synthesized to investigate the structure-activity relationship of this class of inhibitor. Each analogue was evaluated for human isoform selectivity. One analogue, S-ethyl N-[4-(trifluoromethyl)phenyl]isothiourea (39), exhibited 115-fold and 29-fold selectivity for the neuronal isoform versus the inducible and endothelial derived constitutive isoforms, respectively. Studies have shown the substituted N-phenylisothiourea 39 binds competitively with L,-arginine.

Nitrogen heterocyclic carboximidamide compounds

5-, 6- or 7-Membered fully saturated 1-azacarbocyclic-2-ylidene derivatives of guanidine having anti-secretory and hypoglycemic activities, and further useful for treatment of cardiovascular disease states.