139768-72-2Relevant academic research and scientific papers
Synthesis and pharmacological evaluation of N,N'-diarylguanidines as potent sodium channel blockers and anticonvulsant agents
Reddy, N. Laxma,Fan, Wenhong,Magar, Sharad S.,Perlman, Michael E.,Yost, Elizabeth,Zhang, Lu,Berlove, David,Fischer, James B.,Burke-Howie, Kathy,Wolcott, Teresa,Durant, Graham J.
, p. 3298 - 3302 (1998)
Synthesis and structure-activity relationships (SAR) are described for a series of N,N'-diarylguanidines related to N-acenaphth-5-yl-N'-(4- methoxynaphth-1-yl)guanidine (3) as anticonvulsants through blockade of sodium channels. SAR studies on compound 3
PROTEIN KINASE INHIBITORS
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Page/Page column 36, (2015/06/08)
The present invention relates to a novel family of protein kinase inhibitors, more specifically the present invention is directed to inhibitors of the members of the Tec or Src protein kinase families. The present invention also relates to the processes of preparation of these compounds, their intermediates, to the pharmaceutical compositions comprising them, and to their use in the treatment of proliferative, inflammatory, autoimmune, or infectious disease, disorders, or conditions in which protein kinase activity is implicated. More particularly, the present invention relates to a compound of Formula I.
Biphenyl-substituted guanidine derivatives useful as hypoglycaemic agents
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, (2008/06/13)
Compounds of formula I STR1 and their salts in which R1 is optionally substituted phenyl, R2 is alkyl, cycloalkyl or optionally substituted amino, or R2 and R3 together with the nitrogen and carbon atoms to which they are attached form an optionally substituted heterocyclic ring or R3 and R4 together with the nitrogen atom to which they are attached form an optionally substituted heterocyclic ring and R5 is H, halo, alkyl, alkoxy, trifluoromethyl or a group of formula S(O)m R8 in which m is 0, 1 or 2 and R8 is alkyl have utility in the treatment of diabetes particularly in the treatment of hyperglycaemia.
