65089-17-0

Usage

Uses

Pirinixil, is an absorbable hypolipidemic agent of low toxicity.

Safety Profile

Suspected carcinogen with experimental carcinogenic data. Mutation data reported. When heated to decomposition it emits very toxic fumes of Cl-, NOx and SOx

InChI:InChI=1/C16H19ClN4O2S/c1-10-4-3-5-12(11(10)2)19-14-8-13(17)20-16(21-14)24-9-15(23)18-6-7-22/h3-5,8,22H,6-7,9H2,1-2H3,(H,18,23)(H,19,20,21)

Upstream product

• 541-41-3 chloroformic acid ethyl ester 
• 141-43-5 ethanolamine 
• 50892-23-4 pirinixic acid 
• 17619-22-6 1-ethyleneimine 
• 65089-38-5 (4,6-dichloro-2-pyrimidinyl-thio)-(N-β-hydroxyethyl)-acetamide 
• 50892-12-1 ethyl <<4,6-dichloro-2-pyrimidinyl>thio>acetate 
• 91759-33-0 ethyl <<4-chloro-6-<(2,3-dimethylphenyl)oxy>-2-pyrimidinyl>thio>acetate 
• 50892-49-4 ethyl [(4,6-dihydroxypyrimidin-2-yl)-sulfanyl]acetate 
• 151-56-4 ethyleneimine 

Downstream Products

• 91759-34-1 <<4-chloro-6--2-pyrimidinyl>thio>-N-(2-hydroxyethyl)acetamide 

Relevant academic research and scientific papers

Novel pyrimidine and 1,3,5-triazine hypolipidemic agents

New compounds were synthesized by changing the substituents of a trisubstituted pyrimidine, i.e., [[4-chloro-6-[(2,3-dimethylphenyl)amino]-2-pyrimidinyl]thio]acetic acid, a potent hypolipidemic agent, impaired, however, by a marked hepatomegaly-inducing effect. The structural variations led to the subsidence (14b, i.e., 4-chloro-2-(dimethylamino)-6-[(2,3-dimethylphenyl)amino]pyrimidine) or to the reduction (18b, [[4-chloro-6-[(2,3-dimethylphenyl)amino]-2-pyrimidinyl]amino]acetic acid) of said untoward effect but still maintained the hypolipidemic effect that, although markedly decreased, still proves significant for serum cholesterol and triglycerides (18b) or for serum triglycerides only (14b).

(2-Pyrimidinyl-thio)-alkanoic acid amides and their preparation

The invention provides novel amides of (2-pyrimidinyl-thio)-alkanoic acids having antilipemic activity combined with a lower toxicity than the corresponding acids.