65096-22-2

Upstream product

• 35166-51-9 methyl ester of N^α-benzoyl-N^?-methyl-L-histidine 
• 98-88-4 benzoyl chloride 
• 3005-62-7 methyl ester of N^α-benzoyl-L-histidine 
• 125039-07-8 (S)-2-Benzoylamino-3-[1-(4-nitro-benzenesulfonyl)-1H-imidazol-4-yl]-propionic acid methyl ester 

Relevant academic research and scientific papers

Kinetic resolution of racemic alcohols catalyzed by minimal artificial acylases derived from l-histidine

The artificial acylases, tert-butyldiphenylsilyl ether and tris(trimethylsilyl)silyl ether of N(π)-methyl-N(α)-(2,4,6-triisopropylbenzenesulfonyl)-l-histidinol, are simple and small molecules, which contain only one chiral carbon center that originates from natural l-histidine. Asymmetric acylation of racemic secondary alcohols with isobutyric anhydride induced by these artificial acylases gave optically active isobutyrates and optically active alcohols with an S(kfast-reacting enantiomer/kslow-reacting enantiomer) value of up to 132. One hydrogen bonding interaction between a sulfonamidyl group of the catalysts and a substrate should be essential for inducing the high level of kinetic resolution through catalytic asymmetric acylation. Furthermore, a reusable polystyrene-bound artificial acylase was developed to examine its practicality.

Rational design of an L-histidine-derived minimal artificial acylase for the kinetic resolution of racemic alcohols

This communication describes the rational design of an l-histidine-derived minimal artificial acylase. Our new artificial acylase, tert-butyldiphenylsilyl ether of N-(2,4,6-triisopropylbenzenesulfonyl)-π(Me)-l-histidinol, is a simple and small molecule (m