651-12-7

Usage

Uses

Used in Pharmaceutical Industry:
1,4-BIS(BROMODIFLUOROMETHYL)BENZENE is used as a reagent in the synthesis of pharmaceuticals for its ability to contribute to the creation of complex organic molecules that can be used in the development of new drugs.
Used in Agrochemical Industry:
Similarly, in the agrochemical sector, 1,4-BIS(BROMODIFLUOROMETHYL)BENZENE is employed as a reagent in the production of various agrochemicals, potentially aiding in the development of pesticides and other agricultural products.
Used in Electronics Industry:
1,4-BIS(BROMODIFLUOROMETHYL)BENZENE is also used in the production of electronic materials, where its unique properties may contribute to the development of advanced electronic components or materials with specific characteristics.
Used in Polymer Industry:
Furthermore, 1,4-BIS(BROMODIFLUOROMETHYL)BENZENE is utilized in the synthesis of polymers, which can have a range of applications from plastics to specialty materials used in various industries.
Considering its low toxicity and minimal expected risks to human health or the environment when handled properly, 1,4-BIS(BROMODIFLUOROMETHYL)BENZENE is a valuable component in the synthesis of a variety of products across different industries.

InChI:InChI=1/C8H4Br2F4/c9-7(11,12)5-1-2-6(4-3-5)8(10,13)14/h1-4H

Upstream product

• 106-42-3 para-xylene 
• 2250-36-4 1-(bromodifluoromethyl)-4-(difluoromethyl)benzene 
• 623-27-8 terephthalaldehyde, 
• 1592-31-0 1,4-bis(dibromomethyl)benzene 
• 658-18-4 1,4-bis(difluoromethylene)cyclohexane 
• 369-54-0 p-bis(difluoromethyl)benzene 

Downstream Products

• 3345-29-7 1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane 
• 3200-26-8 α,α'-Bis-(ethylthio)-α,α,α',α'-tetrafluor-p-xylol 
• 433-19-2 1,4-bis(trifluoromethyl)benzene 
• 3200-23-5 α,α'-Bis-(butylsulfonyl)-α,α,α',α'-tetrafluor-p-xylol 
• 3200-22-4 α,α'-Bis-(propylsulfonyl)-α,α,α',α'-tetrafluor-p-xylol 
• 3200-21-3 α,α'-Bis-(ethylsulfonyl)-α,α,α',α'-tetrafluor-p-xylol 
• 3200-13-3 α,α'-Bis-(butylthio)-α,α,α',α'-tetrafluor-p-xylol 
• 3200-28-0 α,α'-Bis-(propylthio)-α,α,α',α'-tetrafluor-p-xylol 

Relevant academic research and scientific papers

Synthesis of trifluoromethyl moieties by late-stage copper (I) mediated nucleophilic fluorination

The nucleophilic fluorination of bromodifluoromethyl derivatives mediated by the complex (PPh3)3CuF is described. Under the reaction conditions, different trifluoroacetates, trifluoroketones, trifluoroarenes and trifluoroacetamides were obtained in good yields.

Method and device for purifying 1,4-bis (bromodifluoromethyl) benzene

A method and a device for purifying 1,4-bis(bromodifluoromethyl)benzene are disclosed. In order to solve the problem of hard to purify and separate 1,4-bis(bromodifluoromethyl)benzene crude products, diphenylmethane that has a higher boiling point and does not interact with 1,4-bis(bromodifluoromethyl)benzene is mixed with the 1,4-bis(bromodifluoromethyl)benzene crude products for evaporation. Afterwards, the purity of the vaporized product is detected and only that reaching an expected purity is collected to obtain high-purity 1,4-bis(bromodifluoromethyl)benzene.

Method for production of halogen-containing aromatic compound

This invention relates to a method for the production of an aromatic compound (II) having a (CH2)nCX2Br group (wherein X represents a fluorine or chlorine atom and the X's may be same or different, and n is an integer in the range of 0 to 4) by the reaction of photo-bromination of an aromatic compound (I) having a (CH2)nCX2H group (wherein X and n are as defined above) with a brominating agent, wherein the photo-bromination reaction is carried out while removing hydrogen bromide generated in the reaction system and/or in an atmosphere of a low oxygen content, and a halogen-containing naphthalene compound represented by the following formula (1): wherein Y represents —CF2H, —CF2Br, or —CHO group, Z1and Z2independently represent a halogen atom, and p and q independently are an integer in the range of 0 to 3.

SYNTHESIS OF 1,1,2,2,9,9,10,10-OCTAFLUORO-PARA-CYCLOPHANE

1,1,2,2,9,9,10,10-Octafluoro-para-cyclophane was obtained by the pyrolysis of α,α'-di-bromo-α,α,α',α'-tetrafluoro-p-xylene using argon as the diluent with further trapping of the pyrolysis products in boiling toluene.The pyrolysis zone was filled with a copper packing to bind bromine.An efficient scheme was also developed for the preparation of α,α'-dibromo-α,α,α',α'-tetrafluoro-p-xylene starting from p-xylene.

A New Synthesis of Octafluoroparacyclophane

A new synthesis of 1,1,2,2,9,9,10,10-octafluoroparacyclophane (2) is reported.Easy preparation of gram quantities of 2 is accomplished by treatment of α,α'-dibromo-α,α,α',α'-tetrafluoroxylene with a complex low-valent form of Ti which is made by reduction of TiCl4 with equimolar quantities of LiAlH4 in THF.Use of high-dilution techniques is required for the reaction to be successful.The formation of 2 is believed to proceed via the reactive monomeric species α,α,α',α'-tetrafluoro-p-xylylene (4).