369-54-0

Usage

Chemical Properties

clear colorless liquid

InChI:InChI=1/C7H6F3NS/c8-7(9,10)12-6-3-1-2-5(11)4-6/h1-4H,11H2

Upstream product

• 623-27-8 terephthalaldehyde, 
• 7398-82-5 p-bis-(dichloromethyl)benzene 
• 637-87-6 1-Chloro-4-iodobenzene 
• 589-87-7 1,4-bromoiodobenzene 
• 24588-68-9 2,2'-p-phenylene-bis-[1,3]dithiane 
• 69922-37-8 2,2'-p-phenylene-bis-[1,3]dithiolane 
• 106-42-3 para-xylene 
• 1592-31-0 1,4-bis(dibromomethyl)benzene 

Downstream Products

• 2629-68-7 1,4-bis-(difluorochloromethyl)-benzene 
• 2250-30-8 α,α,α',α'-tetrafluoro-p-xylylene 
• 3345-29-7 1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane 
• 2250-36-4 1-(bromodifluoromethyl)-4-(difluoromethyl)benzene 
• 651-12-7 α,α'-dibromo-α,α,α',α'-tetrafluoro-p-xylene 
• 1743-00-6 4-fluoro-β,β-difluorostyrene 
• 106-42-3 para-xylene 
• 3200-13-3 α,α'-Bis-(butylthio)-α,α,α',α'-tetrafluor-p-xylol 
• 3200-28-0 α,α'-Bis-(propylthio)-α,α,α',α'-tetrafluor-p-xylol 
• 3200-26-8 α,α'-Bis-(ethylthio)-α,α,α',α'-tetrafluor-p-xylol 
• 3200-23-5 α,α'-Bis-(butylsulfonyl)-α,α,α',α'-tetrafluor-p-xylol 
• 3200-22-4 α,α'-Bis-(propylsulfonyl)-α,α,α',α'-tetrafluor-p-xylol 
• 3200-21-3 α,α'-Bis-(ethylsulfonyl)-α,α,α',α'-tetrafluor-p-xylol 

Relevant academic research and scientific papers

Microwave-assisted synthesis of 1,4-bis(difluoromethyl)benzene

A fast, mild, and practical microwave-assisted protocol for synthesis of 1,4-bis(difluoromethyl)benzene from 1,4-bis(dichloromethyl)benzene and KF was developed. The new protocol increased the yield and reduced the reaction time significantly in contrast to the conventional heating procedure. Also, the synergistic effect of a composite phase transfer catalyst was studied.

Direct Difluoromethylation of Aryl Halides via Base Metal Catalysis at Room Temperature

A stable and isolable difluoromethyl zinc reagent has been prepared through the reaction of ICF2H with diethyl zinc and DMPU. This new zinc reagent is a free-flowing solid and can be used in combination with a nickel catalyst to difluoromethylate aryl iodides, bromides, and triflates at room temperature. Such mild conditions for the catalytic difluoromethylation of these substrates are unprecedented.

Preparation of Mono-/Difluorinated Hydrocarbon Compounds

Mono- or difluorinated hydrocarbon compounds are prepared from an alcohol or a carbonylated compound by reacting one of these with a fluorinating reagent, optionally in the presence of a base, the fluorinating agent comprising a pyridinium reactant having the following formula (F), wherein R0 is an alkyl or cycloalkyl radical:

Efficient synthesis of p-bis-(chlorodifluoromethyl)benzene

Selective, high yield partial fluorination of p-bis-(trichloromethyl)benzene to p-bis-(chlorodifluoromethyl)benzene has been accomplished by warming a slurry of the p-bis-(trichloromethyl)benzene in anhydrous HF which also contains a small quantity of inert solvent, such as 1,2-dichloroethane.

Method for synthesizing TFPX

A method for the synthesis of TFPX (α,α,α′,α′-tetrafluoro-p-xylene) is disclosed, which comprises the following steps: (a) providing a sulpholane solution comprising TCPX (α,α,α′,α′-tetrachloro-p-xylene); (b) mixing the sulpholane solution with alkali metal fluoride, and phase transfer catalyst to form a mixture, wherein the phase transfer catalyst is quaternary phosphonium salt; and (c) heating the mixture.

Method for transferring TCPX into TFPX

A method for transferring TCPX (α, α, α′, α′-tetrachloro-p-xylene) into TFPX (α, α, α′, α′-tetrafluoro-p-xylene) is disclosed, which comprises the following steps: (a) providing a first reactant comprising TFPX; (b) mixing the first reactant with alkali metal fluorides, TCPX and phase transfer catalyst(s) to form a mixture, wherein the alkali metal fluorides is KF, CsF, NaF, LiF or the combination thereof, the phase transfer catalyst(s) is quaternary ammonium salt, quaternary phosphonium salt or the combination thereof; and (c) heating the mixture.

METHOD FOR THE PREPARATION OF ALPHA,ALPHA,ALPHA',ALPHA'-TETRAFLUORO-P-XYLENE

A method for the preparation of α,α,α′,α′-tetrafluoro-p-xylene is disclosed. α,α,α′,α′-tetrachloro-p-xylene and KF and a small amount of phase transfer catalyst are dissolved in solvent, xylene, and undergo a recycle reaction for 48 hours, after which 60% of the product is obtained.

Process for production of 1,4-bis(difluoroalkyl)benzene derivative

A process is provided which allows a 1,4-bis(difluoroalkyl)benzene derivative to be produced inexpensively by a simple procedure without requiring any special facility. This process comprises causing a compound (A) of the following formula (1): wherein X1, X2, X3, and X4 independently stand for an oxygen or sulfur atom, Y1 and Y2 independently stand for a group of the formula: —CnH2n—, in which n is 2 or 3, k is an integer in the range of 0 to 4, G stands for a halogen group, an alkyl group, a perfluoroalkyl group, or an alkoxy group, and m is an integer in the range of 0 to 4, to react with a fluorine-containing species, the molar ratio of the fluorine-containing species to compound (A) being in the range of 20-40. The process is carried out in the presence of a bromine-containing compound, which is in an amount of 2 to 3 equivalences to the amount of compound (A), in an organic solvent at ?80° C. to 30° C., the final concentration of compound (A) being in the range of 3 to 30% by weight.

Process for production of 1,4-bis (difluoroalkyl) benzene derivative

A process is provided which allows a 1,4-bis(difluoroalkyl)benzene derivative to be produced inexpensively by a simple procedure without requiring any special facility. This process comprises causing a compound (A) of the following formula (1): wherein X1, X2, X3, and X4 independently stand for an oxygen or sulfur atom, Y1 and Y2 independently stand for a group of the formula: —CnH2n—, in which n is 2 or 3, k is an integer in the range of 0 to 4, G stands for a halogen group, an alkyl group, a perfluoroalkyl group, or an alkoxy group, and m is an integer in the range of 0 to 4, to react with a fluorine-containing species, the molar ratio of the fluorine-containing species to compound (A) being in the range of 20-40. The process is carried out in the presence of a bromine-containing compound, which is in an amount of 2 to 3 equivalences to the amount of compound (A), in an organic solvent at ?80° C. to 30° C., the final concentration of compound (A) being in the range of 3 to 30% by weight.