651059-45-9Relevant academic research and scientific papers
A Mechanism-Based Inhibitor Targeting the DD-Transpeptidase Activity of Bacterial Penicillin-Binding Proteins
Lee, Mijoon,Hesek, Dusan,Suvorov, Maxim,Lee, Wenlin,Vakulenko, Sergei,Mobashery, Shahriar
, p. 16322 - 16326 (2007/10/03)
Penicillin-binding proteins (PBPs) are responsible for the final stages of bacterial cell wall assembly. These enzymes are targets of β-lactam antibiotics. Two of the PBP activities include DD-transpeptidase and DD-carboxypeptidase activities, which carry
