65112-72-3Relevant academic research and scientific papers
Indole β-Nucleophilic Substitution. Part 2. Formation of a Benzoxepinoindole and a Pyridooxepinoindole
Cooper, Melanie M.,Hignett, Geoffrey J.,Joule, John A.
, p. 3008 - 3011 (2007/10/02)
The synthesis are described of benzoxepinoindol-11(6H,12H)-one, (12a) and 12-methylpyridooxepinoindol-5(6H,12H)-one, (5), by sequences involving the first examples of intramolecular nucleophilic substitution at an indole β-position, with departure of phenylsulphinate as leaving group from nitrogen.The spectroscopic and chemical evidence supporting the structures for these new heterocyclic systems, and thus by implication the operation of indole β-nucleophilic substitution, are detailed.
