65130-47-4

Upstream product

• 620-16-6 3-chloroethylbenzene 
• 2039-85-2 3-Chlorostyrene 
• 672-65-1 (1-chloroethyl)benzene 

Downstream Products

• 14161-84-3 2-(3-chlorophenyl) propanoic acid 
• 1066-37-1 trimethylbromogermane 
• 1066-44-0 trimethyltin bromide 
• 1358804-52-0 1-(1-(3-chlorophenyl)ethyl)cyclobutanecarbonitrile 
• 1358804-53-1 C₁₈H₁₈ClNO 
• 1358803-57-2 {1-[1-(3-chlorophenyl)ethyl]cyclobutyl}(pyridin-2-yl)methanol 
• 120121-01-9 1-(m-Chlorophenyl)ethanol 
• 1610950-01-0 1-chloro-3-(1-(o-tolyl)ethyl)benzene 
• 1610950-02-1 1-chloro-3-(1-(m-tolyl)ethyl)benzene 
• 882753-05-1 1-chloro-3-(1-(p-tolyl)ethyl)benzene 
• 1610950-00-9 C₁₆H₂₅ClO 

Relevant academic research and scientific papers

Scalable anti-Markovnikov hydrobromination of aliphatic and aromatic olefins

To improve access to a key synthetic intermediate we targeted a direct hydrobromination-Negishi route. Unsurprisingly, the anti-Markovnikov addition of HBr to estragole in the presence of AIBN proved successful. However, even in the absence of an added initiator, anti-Markovnikov addition was observed. Re-examination of early reports revealed that selective Markovnikov addition, often simply termed "normal" addition, is not always observed with HBr unless air is excluded, leading to the rediscovery of a reproducible and scalable initiator-free protocol.

MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF

Agents for modulating methyl modifying enzymes, compositions and uses thereof are provided herein.

Direct and selective benzylic oxidation of alkylarenes via C-H abstraction using alkali metal bromides

A direct benzylic oxidation of alkylarenes via C-H bond abstraction was developed using alkali metal bromides and oxidants under mild conditions. This reaction proceeded with excellent selectivity by thermal oxidation or photooxidation to provide a broad range of carbonyl compounds containing electron-deficient aryl carbonyl compounds in high yields.

A practical synthesis of indanofan via one-pot bromination of 3- chloroethylbenzene

A practical synthesis of Indanofan (1), a potent herbicide discovered by Mitsubishi Chemical Co. Ltd., was achieved starting from commercially available 3-chloroethylbenzene (2). 3-Chloro-α-bromostyrene (3), which was converted to 1-chloro-2-(3-chlorophenyl)prop-2-ene (5) in 2 steps, was synthesized via one-pot bromination of 2. 2-Ethylindane-1,3-dione (6) was synthesized from ethyl butyrate and ethyl phthalate (11) using NaOEt. The coupling reaction of 5 with 6 followed by oxidation with AcOOH afforded 1 in a high overall yield.

3-substituted-α, β-dibromoethylbenzene and process for preparing the same

A novel 3-substituted α,β-dibromoethylbenzene of formula (I): STR1 wherein X represents a halogen atom or a trihalomethyl group, which is useful as an intermediate for pharmaceuticals or agricultural chemicals, is prepared by a simple and high yield proce

Process for the preparation of chloroarylacetylene precursors

Chloroarylacetylenes such as m-chlorophenylacetylene and certain precursors to such chloroarylacetylene are prepared by reacting a chloroarylbromide with a substituted terminal acetylene compound containing at least three carbon atoms and a hydroxy group on the carbon atom adjacent to the acetylene group in the presence of a dialkyl or trialkyl amine solvent and a catalyst system consisting of a palladium complex containing two halogen moieties and two tri-substituted phosphine moieties. Additional triphenylphosphine can be added. A cuprous iodide promoter is also employed in the reaction sequence.