651335-60-3 Usage
Chemical structure
An indole ring substituted with a pyrrolidine and a phenylsulfonyl group.
Explanation
The compound consists of an indole ring system with additional pyrrolidine and phenylsulfonyl groups attached to it.
Explanation
1H-Indole, 1-[1-(phenylmethyl)-3-pyrrolidinyl]-3-(phenylsulfonyl)- is not found naturally and is created through chemical synthesis.
Explanation
The compound's unique structure and properties make it a potential candidate for investigating its effects on biological systems and its potential as a therapeutic agent.
Explanation
The presence of these groups on the indole ring may affect the compound's interactions with biological systems, making it a valuable subject for research.
Explanation
The presence of a sulfone group can influence the compound's chemical and biological properties, potentially affecting its therapeutic potential.
Explanation
The unique structure and properties of 1H-Indole, 1-[1-(phenylmethyl)-3-pyrrolidinyl]-3-(phenylsulfonyl)- make it a promising candidate for the development of novel pharmaceuticals and therapeutic approaches.
Synthetic compound
Can be synthesized in the laboratory.
Pharmaceutical research and development
Used in the study of biological activity and drug design.
Pyrrolidine and phenylmethyl groups
Contribute to the compound's biological activity.
Phenylsulfonyl group
Adds a sulfone functionality to the molecule.
Medicinal chemistry and pharmacology applications
Potential use in the development of new drugs and therapies.
Check Digit Verification of cas no
The CAS Registry Mumber 651335-60-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,5,1,3,3 and 5 respectively; the second part has 2 digits, 6 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 651335-60:
(8*6)+(7*5)+(6*1)+(5*3)+(4*3)+(3*5)+(2*6)+(1*0)=143
143 % 10 = 3
So 651335-60-3 is a valid CAS Registry Number.
651335-60-3Relevant academic research and scientific papers
3-(Arylsulfonyl)-1-(azacyclyl)-1H-indoles are 5-HT6 receptor modulators
Bernotas, Ronald C.,Antane, Schuyler,Shenoy, Rajesh,Le, Van-Duc,Chen, Ping,Harrison, Boyd L.,Robichaud, Albert J.,Zhang, Guo Ming,Smith, Deborah,Schechter, Lee E.
scheme or table, p. 1657 - 1660 (2010/07/03)
Novel 3-(arylsulfonyl)-1-(azacyclyl)-1H-indoles 6 were synthesized as potential 5-HT6 receptor ligands, based on constraining a basic side chain as either a piperidine or a pyrrolidine. Many of these compounds had good 5-HT6 binding affinity with Ki values 50 = 60 nM, Emax = 70%) and antagonists (6y: IC50 = 17 nM, Imax = 86%) were identified in a 5-HT6 adenylyl cyclase assay.
