651335-54-5 Usage
Chemical structure
An indole ring with a phenylsulfonyl group and a pyrrolidinyl group attached to it.
Use
Often used as a building block in the synthesis of various pharmaceutical compounds and other organic molecules.
Versatility
The presence of the indole ring and the sulfonyl group make it a versatile molecule for creating diverse chemical structures for a range of applications.
Functionality
The pyrrolidinyl group adds another dimension of functionality to the compound, making it a valuable tool for chemical synthesis and drug discovery efforts.
Check Digit Verification of cas no
The CAS Registry Mumber 651335-54-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,5,1,3,3 and 5 respectively; the second part has 2 digits, 5 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 651335-54:
(8*6)+(7*5)+(6*1)+(5*3)+(4*3)+(3*5)+(2*5)+(1*4)=145
145 % 10 = 5
So 651335-54-5 is a valid CAS Registry Number.
651335-54-5Relevant academic research and scientific papers
3-(Arylsulfonyl)-1-(azacyclyl)-1H-indoles are 5-HT6 receptor modulators
Bernotas, Ronald C.,Antane, Schuyler,Shenoy, Rajesh,Le, Van-Duc,Chen, Ping,Harrison, Boyd L.,Robichaud, Albert J.,Zhang, Guo Ming,Smith, Deborah,Schechter, Lee E.
scheme or table, p. 1657 - 1660 (2010/07/03)
Novel 3-(arylsulfonyl)-1-(azacyclyl)-1H-indoles 6 were synthesized as potential 5-HT6 receptor ligands, based on constraining a basic side chain as either a piperidine or a pyrrolidine. Many of these compounds had good 5-HT6 binding affinity with Ki values 50 = 60 nM, Emax = 70%) and antagonists (6y: IC50 = 17 nM, Imax = 86%) were identified in a 5-HT6 adenylyl cyclase assay.
