651355-74-7

Upstream product

• 236117-59-2 (R)-2-((S)-(tert-Butyl-dimethyl-silanyloxy)-{(2S,3R)-3-[(S)-2-(4-methoxy-benzyloxy)-1-methyl-ethyl]-2-methyl-oxiranyl}-methyl)-but-3-en-1-ol 
• 651356-55-7 (3R,4R,5R,6S,7S)-7-(tert-Butyl-dimethyl-silanyloxy)-4,6-bis-(tert-butyl-dimethyl-silanyloxymethyl)-3,5-dihydroxy-7-{(2S,3R)-3-[(S)-2-(4-methoxy-benzyloxy)-1-methyl-ethyl]-2-methyl-oxiranyl}-heptanoic acid methoxy-methyl-amide 
• 651355-70-3 (R)-3-((2R,3S,4S,5S)-5-(tert-Butyl-dimethyl-silanyloxy)-4-(tert-butyl-dimethyl-silanyloxymethyl)-3-hydroxy-5-{(2S,3R)-3-[(S)-2-(4-methoxy-benzyloxy)-1-methyl-ethyl]-2-methyl-oxiranyl}-2-vinyl-pentanoyl)-4-isopropyl-oxazolidin-2-one 
• 651355-72-5 (1S,2S,3R,4S)-1-(tert-Butyl-dimethyl-silanyloxy)-2,4-bis-(tert-butyl-dimethyl-silanyloxymethyl)-1-{(2S,3R)-3-[(S)-2-(4-methoxy-benzyloxy)-1-methyl-ethyl]-2-methyl-oxiranyl}-hex-5-en-3-ol 
• 651355-73-6 (2S,3S,4S,5S)-5-(tert-Butyl-dimethyl-silanyloxy)-2,4-bis-(tert-butyl-dimethyl-silanyloxymethyl)-3-hydroxy-5-{(2S,3R)-3-[(S)-2-(4-methoxy-benzyloxy)-1-methyl-ethyl]-2-methyl-oxiranyl}-pentanal 
• 651355-71-4 (2S,3R,4S,5S)-5-(tert-Butyl-dimethyl-silanyloxy)-4-(tert-butyl-dimethyl-silanyloxymethyl)-5-{(2S,3R)-3-[(S)-2-(4-methoxy-benzyloxy)-1-methyl-ethyl]-2-methyl-oxiranyl}-2-vinyl-pentane-1,3-diol 
• 651355-67-8 (2S,3R)-2-[(1S,2R)-1-(tert-Butyl-dimethyl-silanyloxy)-2-(tert-butyl-dimethyl-silanyloxymethyl)-but-3-enyl]-3-[(S)-2-(4-methoxy-benzyloxy)-1-methyl-ethyl]-2-methyl-oxirane 
• 651355-69-0 (2R,3S)-3-(tert-Butyl-dimethyl-silanyloxy)-2-(tert-butyl-dimethyl-silanyloxymethyl)-3-{(2S,3R)-3-[(S)-2-(4-methoxy-benzyloxy)-1-methyl-ethyl]-2-methyl-oxiranyl}-propionaldehyde 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 78191-00-1 N-Methoxy-N-methylacetamide 

Downstream Products

• 651355-78-1 (3S,4R,6R,7S)-3,7-Bis-(tert-butyl-dimethyl-silanyloxy)-4,6-bis-(tert-butyl-dimethyl-silanyloxymethyl)-7-{(2S,3R)-3-[(S)-2-(4-methoxy-benzyloxy)-1-methyl-ethyl]-2-methyl-oxiranyl}-5-oxo-heptanoic acid methoxy-methyl-amide 
• 651355-76-9 (3S,4S,5R,6S,7S)-3,7-Bis-(tert-butyl-dimethyl-silanyloxy)-4,6-bis-(tert-butyl-dimethyl-silanyloxymethyl)-5-hydroxy-7-{(2S,3R)-3-[(S)-2-(4-methoxy-benzyloxy)-1-methyl-ethyl]-2-methyl-oxiranyl}-heptanoic acid methoxy-methyl-amide 

Relevant academic research and scientific papers

Total synthesis of natural myriaporones

The relative and absolute configuration of the cytotoxic myriaporones. (e.g. 4) was assigned by their total synthesis from aldehyde 1. Key steps included aldol reactions with chiral oxazolidinone 2 and with Weinreb amide 3. TBS = tert-butyldimethylsilyl,

TOTAL SYNTHESIS OF MYRIAPORONES

Compounds of the general formula (I) or a pharmaceutically acceptable salt, derivative, prodrug or stereoisomer thereof are provided: wherein the substituent groups defined by R are each independently selected from the group consisting of H, SiR'3/s