65148-09-6

Usage

Uses

Used in Pharmaceutical Research and Development:
2-Quinolinecarboxamide, 6-bromois used as a chemical intermediate in the synthesis of various pharmaceutical compounds. Its unique structural features and potential biological activities make it a valuable building block for the development of new drugs and therapeutic agents.
Used in Drug Discovery:
2-Quinolinecarboxamide, 6-bromois used as a starting material in drug discovery programs. Its structural features and potential biological activities make it a promising candidate for the development of new drugs with novel mechanisms of action.
Used in Medicinal Chemistry:
2-Quinolinecarboxamide, 6-bromois used as a key component in the design and synthesis of new chemical entities with potential therapeutic applications. Its unique structural features and potential biological activities make it a valuable tool for medicinal chemists in the development of innovative drug candidates.

Upstream product

• 65185-41-3 6-bromoquinoline-2-carbonitrile 
• 877-42-9 6-Bromo-2-methyl-quinoline 
• 5332-25-2 6-bromoquinoline 
• 563-41-7 semicarbazide hydrochloride 
• 77287-34-4 formamide 

Relevant academic research and scientific papers

Transition-metal-free synthesis of primary to tertiary carboxamides: A quick access to prodrug-pyrazinecarboxamide

One-pot expedient and direct carbamoylation of heterocyclics is described. The transformation is realized via direct dehydrogenative aminocarbonylation of heterocyclic compounds under transition-metal-free conditions. This method is regioselective and the protocol is proved to be scalable on a gram scale. Further, the therapeutically useful antitubercular agent pyrazinecarboxamide is successfully synthesized by employing this protocol.

Highly Regioselective Carbamoylation of Electron-Deficient Nitrogen Heteroarenes with Hydrazinecarboxamides

The use of hydrazinecarboxamides as a new class of carbamoylating agents has been established through the dehydrazinative Minisci reaction of electron-deficient nitrogen heteroarenes. A wide range of electron-deficient nitrogen heteroarenes, including isoquinoline, quinoline, pyridine, phenanthridine, quinoxaline, and phthalazine, underwent copper/acid-catalyzed oxidative carbamoylation with hydrazinecarboxamide hydrochlorides to afford structurally diverse nitrogen-heteroaryl carboxamides as single regioisomers in moderate to excellent yields. The functional group tolerance was substantially demonstrated in the direct carbamoylation of quinine obviating multistep sequences involving protecting groups and prefunctionalization of the heterocycle.

Copper catalysed direct amidation of methyl groups with N-H bonds

An efficient copper catalyzed direct aerobic oxidative amidation of methyl groups of azaarylmethanes with N-H bonds producing amides is successfully developed, which can produce primary, secondary and tertiary amides, including those with functional groups. This reaction represents a straightforward method for the preparation of amides from the readily available hydrocarbon starting materials.

GEMINALLY SUBSTITUTED CYANOETHYLPYRAZOLO PYRIDONES AS JANUS KINASE INHIBITORS

The instant invention provides compounds of Formula (I) which are JAK inhibitors, and as such are useful for the treatment of JAK-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer.