65149-73-7

Usage

Uses

Used in Organic Chemistry:
2-[(pyridin-2-ylmethyl)amino]ethanethiol is used as a reagent in organic chemistry for its ability to participate in various chemical reactions, facilitating the synthesis of complex organic molecules.
Used in Pharmaceutical Synthesis:
In the pharmaceutical industry, 2-[(pyridin-2-ylmethyl)amino]ethanethiol is used as a key intermediate in the synthesis of various pharmaceuticals, contributing to the development of new drugs with potential therapeutic applications.
Used in Agrochemical Synthesis:
Similarly, in agrochemicals, 2-[(pyridin-2-ylmethyl)amino]ethanethiol is utilized as a reagent in the synthesis of compounds that can be used in the development of pesticides and other agricultural chemicals to protect crops and enhance yields.
Used in Metal Ion Chelation:
2-[(pyridin-2-ylmethyl)amino]ethanethiol is studied for its potential applications in metal ion chelation, where it can form stable complexes with metal ions, useful in various industrial processes and potentially in environmental remediation.
Used as a Corrosion Inhibitor:
In the field of materials protection, 2-[(pyridin-2-ylmethyl)amino]ethanethiol has been investigated for its ability to act as a corrosion inhibitor, helping to prevent the degradation of metal surfaces in various industrial applications.

Upstream product

• 420-12-2 thirane 
• 3731-51-9 2-(Aminomethyl)pyridine 
• 156-57-0 2-mercaptoethylamine hydrochloride 
• 31106-82-8 2-(bromomethyl)pyridine hydrobromide 
• 108-24-7 acetic anhydride 
• 80508-81-2 glaucocalyxin B 

Downstream Products

• 166899-92-9 2-(2-Pyridyl)-3-(2-pyridylmethyl)-1,3-thiazolidine 
• 465512-06-5 2-[N-benzyl-N-(2-mercaptoethyl)]aminomethylpyridine 
• 465512-07-6 2-[N-(4-tert-butylbenzyl)-N-(2-mercaptoethyl)]aminomethylpyridine 
• 465512-08-7 2-[N-(3,5-di-tert-butylbenzyl)-N-(2-mercaptoethyl)]aminomethylpyridine 
• 163232-67-5 [Zn(NC₅H₄CH₂NHCH₂CH₂S)(O₂CCH₃)]2 
• 163232-68-6 Zn(NC₅H₄CH₂NHCH₂CH₂S)2 
• 163232-71-1 Zn(NC₅H₄CH₂NHCH₂CH₂S)Br 
• 163232-65-3 Zn(NC₅H₄CH₂NHCH₂CH₂S)Cl 

Relevant academic research and scientific papers

Minimum structural requirements for inhibitors of the zinc finger protein TRAF6

Zinc fingers have rarely been regarded as drug targets. On the contrary, the zinc-binding site of enzymes has often been considered a target of inhibitors. We previously developed a dithiol compound called SN-1 that binds to the zinc finger protein tumor necrosis factor receptor-associated factor 6 (TRAF6) and suppresses downstream nuclear factor-κB (NF-κB) signaling. To determine the minimal structure requirements of TRAF6 inhibitors based on SN-1, NF-κB inhibitory activity and cytotoxicity of its derivatives including new compounds were examined. SN-2, an oxidative type of prodrug of SN-1 with 2-nitrophenylthio groups via disulfide, has the minimum structure for an inhibitor of TRAF6, as seen with cellular experiments. The importance of two side chains with a thiol group was shown with molecular modelling. This study may lead to development of selective TRAF6 inhibitors in the near future.

Synthesis and characterization of iron(II) carbonyl complexes related to cluster-free hydrogenase

Reactions of [Fe(CO)4I2] with one equivalent of PyCH2NHC2H4SNa (L1- Na+) and PyCH2NH2 (L2) in THF separately gave rise to complexes [Fe(CO)2(L1)I] (1) and [Fe(CO) 2(L2)I2] (2). Both the complexes show two strong carbonyl absorptions at 2027, 1974 cm-1 (1) and 2036, 1989 cm-1 (2), which are very close to that of cluster-free hydrogenase (Hmd).

New organometallic dioxotungsten(VI) complexes containing N2S tridentate ligands: The synthesis and reactivity of chloro and alkyl derivatives

A new series of N-benzyl aliphatic N2S tridentate proligands HLSn (n = 2-4) derived from 2-[(2-mercaptoethyl)-aminomethyl]pyridine (HL1) has been prepared via the sequential reactions of trimethylsilylation, N-benzylation, and hydrolysis. A previously reported aromatic N2S tridentate proligand, 2-[(2-mercaptophenyl)aminomethyl]pyridine (HL5), is also employed as an ancillary ligand. Reaction of these proligands HLn (n = 1-5) with [WO2Cl2(DME)] (DME = 1,2-dimethoxyethane) in the presence of triethylamine leads to the formation of cis-dioxotungsten(VI) complexes [WO2(Ln)Cl] (n = 1-5). Treatment of the chloro derivatives [WO2(Ln)Cl] (n = 1, 5) with the Grignard reagents RMgX (R= CH2SiMe3, C6H4tBu-4; X = Cl, Br) resulted in ligand substitution reaction and the formation of the first reported alkyl complexes of the type [WO2(Ln)R] (n = 1, 5; R = CH2SiMe3, C6H4tBu-4).

DITERPENOIDS FROM RABDOSIA JAPONICA

Two new diterpenoids named glaucocalyxin D and E, as well as three known diterpenoids were isolated from leaves of Rabdosia japonica.Their structures were determined by spectroscopic and chemical data. Key words: Rabdosia japonica; Labiatae; ent-kaurane; diterpene; glaucocalyxin A-E.