65150-68-7 Usage
Uses
Used in Pharmaceutical Industry:
1-(2-deoxy-3,5-di-O-methylpentofuranosyl)-3,5-dimethylpyrimidine-2,4(1H,3H)-dione is used as a potential therapeutic agent for various applications due to its structural characteristics and potential biological activity. Its stability and resistance to degradation make it a promising candidate for the development of new drugs.
Used in Biochemistry Research:
In the field of biochemistry, 1-(2-deoxy-3,5-di-O-methylpentofuranosyl)-3,5-dimethylpyrimidine-2,4(1H,3H)-dione is used as a research tool to study the interactions and mechanisms of nucleosides in biological systems. Its unique structure allows for the investigation of its role in various biochemical processes.
Used in Molecular Biology Applications:
1-(2-deoxy-3,5-di-O-methylpentofuranosyl)-3,5-dimethylpyrimidine-2,4(1H,3H)-dione is utilized in molecular biology for understanding the structure and function of nucleic acids. Its potential biological activity and stability make it a valuable compound for exploring its role in genetic regulation and other molecular processes.
Check Digit Verification of cas no
The CAS Registry Mumber 65150-68-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,5,1,5 and 0 respectively; the second part has 2 digits, 6 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 65150-68:
(7*6)+(6*5)+(5*1)+(4*5)+(3*0)+(2*6)+(1*8)=117
117 % 10 = 7
So 65150-68-7 is a valid CAS Registry Number.
65150-68-7Relevant academic research and scientific papers
In search of Flavivirus inhibitors part 2: Tritylated, diphenylmethylated and other alkylated nucleoside analogues
Saudi, Milind,Zmurko, Joanna,Kaptein, Suzanne,Rozenski, Jef,Neyts, Johan,Van Aerschot, Arthur
, p. 98 - 109 (2014/03/21)
Several flaviviruses, such as the yellow fever virus and the dengue virus cause severe and potentially lethal infection in man. Following up on our initial hit 3′,5′-bistritylated uridine 1, a series of alkylated nucleoside analogues were synthesized and evaluated for their in vitro antiviral activities against dengue fever virus and yellow fever virus. Hereto, alkyl and aryl groups were attached at various positions of the sugar ring combined with subtle variation of the heterocyclic base. Among the new series of derivatives, 3′,5′-di-O-trityl-5-fluoro-2′-deoxyuridine (39) was the most efficient in this series and inhibited both yellow fever virus and dengue virus replication with a 50% effective concentration (EC50) of ～1 μg/mL without considerable cytotoxicity. The other fluorinated derivatives proved more toxic. Almost all diphenylmethylated pyrimidine nucleosides with 3′,5′-di-O-benzhydryl-2′-deoxyuridine (50) as the example were endowed with strong cytotoxic effects down to 1 μg/mL.
