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Usage

Uses

Used in Basic Research:
3-Methylthymidine is utilized as a research tool for studying the role of tRNA methylation in gene expression and regulation. It aids scientists in understanding how the methylation of thymidine impacts the stability and function of tRNAs, which is crucial for decoding genetic information and protein synthesis.
Used in Clinical Applications:
In clinical settings, 3-methylthymidine is employed as a biomarker to assess oxidative stress and DNA damage. Its presence can indicate the extent of cellular stress and potential genetic mutations, which are important for diagnosing and monitoring various diseases and conditions.
Used in Drug Development:
3-Methylthymidine can be used in the development of therapeutic agents targeting tRNA methylation. By modulating the levels of 3-methylthymidine or its metabolic pathways, it may be possible to develop treatments that address specific genetic disorders or conditions related to oxidative stress and DNA damage.
Used in Diagnostics:
3-Methylthymidine can be incorporated into diagnostic tests to detect and measure oxidative stress and DNA damage. These tests can help in the early identification of diseases and conditions, enabling timely intervention and treatment.
Used in Environmental Monitoring:
As a biomarker for oxidative stress and DNA damage, 3-methylthymidine can be used to monitor the impact of environmental factors on human health. This can include assessing the effects of pollutants, radiation, and other environmental stressors on DNA integrity and cellular function.

InChI:InChI=1/C11H16N2O5/c1-6-4-13(11(17)12(2)10(6)16)9-3-7(15)8(5-14)18-9/h4,7-9,14-15H,3,5H2,1-2H3/t7-,8+,9+/m0/s1

Upstream product

• 64969-77-3 hexadecyl-dimethylsulphonium iodide 
• 50-89-5 (+/-)-thymidine 
• 18412-81-2 dodecyl-dimethylsulphonium iodide 

Downstream Products

• 99268-60-7 3',5'-bis(O-pentafluorobenzyl)-3-methylthymidine 
• 50-89-5 thymidine 
• 1585199-26-3 5′-O-benzyl-N³-methyl-thymidine 
• 1585199-27-4 3′-O-benzyl-N³-methyl-thymidine 
• 1585199-25-2 3′,5′-di-O-benzyl-N³-methyl-thymidine 
• 1585199-19-4 5′-O-benzoyl-N³-methyl-thymidine 
• 1585199-22-9 N³-methyl-3′,5′-di-O-trityl-thymidine 
• 122902-47-0 N³-methyl-5′-O-trityl-thymidine 
• 65150-68-7 N³-methyl-3′,5′-di-O-methyl-thymidine 
• 1585199-21-8 N³-methyl-3′-O-trityl-thymidine 
• 1585199-20-7 5′-O-benzoyl-N³-methyl-3′-O-trityl-thymidine 
• 162760-02-3 (Sp)-Thymidylyl-(3'->5')-methyl-4-thiothymidine 3'-(methylphosphonate) 
• 163436-90-6 (Rp)-Thymidylyl-(3'->5')-methyl-4-thiothymidine 3'-(methylphosphonate) 
• 163295-94-1 (Rp)-5'-O-(tert-Butyldiphenylsilyl)thymidylyl-(3'->5')-3'-O-(ter-butyldiphenylsilyl)-N³-methyl-4-thiothymidine 3'-(methylphosphonate) 

Relevant academic research and scientific papers

Micellar Methylating Agents: (Long-chain-alkyl)dimethylsulphonium Iodides

Dodecyl-, hexadecyl-, and octadecyl-dimethylsulphonium iodide were found to methylate efficiently various nucleosides, hydroxy aromatic compounds, and thiols at pH 8-11 and 50 - 70 deg C.The optimum conditions and the mechanism of the reaction are discussed briefly in relation to the micellar reaction characteristics.