65159-48-0

Upstream product

• 122709-86-8 [(E)-4-Nitro-benzylimino]-phenyl-acetic acid 
• 7409-30-5 p-nitrobenzylamine 
• 611-73-4 Benzoylformic acid 

Downstream Products

• 65751-12-4 4-(4-nitro-phenyl)-2,5,5-triphenyl-4,5-dihydro-thiazole 
• 65159-45-7 (4R)-4r-(4-nitro-phenyl)-2,5,5-triphenyl-4,5-dihydro-thiazole 1c-oxide 
• 65159-44-6 1-(4-nitrophenyl)-2,2-diphenylethanone 
• 65159-45-7 (4R)-4r-(4-nitro-phenyl)-2,5,5-triphenyl-4,5-dihydro-thiazole 1t-oxide 

Relevant academic research and scientific papers

X=Y-ZH SYSTEMS AS POTENTIAL 1,3-DIPOLES. PART 20. DECARBOXYLATION OF α-IMINO ACIDS. MECHANIZM AND APPLICATIONS TO THIOAMIDE SYNTHESIS

α-Imino acids, prepared from α-keto acids and primary amines, undergo facile decarboxylation to the corresponding imines on heating at =80 deg C in benzene or methylene chloride.Decarboxylation proceeds via a 1,2-ylide which can be trapped by sulphur to give the corresponding secondary thioamides in good yield. 1,2-Ylides from secondary amines and α-keto acids can be generated in situ and trapped with sulphur to give tertiary thioamides in excellent yield.