65160-21-6

Upstream product

• 5751-48-4 2-methylchromone 

Downstream Products

• 80352-51-8 4-oxo-4H-chromene-2-carbaldehyde-phenylhydrazone 
• 135718-34-2 [Hydroxy-(4-oxo-4H-chromen-2-yl)-methyl]-phosphonic acid dimethyl ester 
• 120757-30-4 C₁₇H₁₄N₂O₄S 
• 5751-48-4 2-methylchromone 
• 59749-54-1 2-(hydroxymethyl)-4H-chromen-4-one 
• 1537888-95-1 7-hydroxy-4-methyl-8-[(4-oxo-4H-chromen-2-yl)[(4-{2-[2-[3-phenylprop-2-en-1-ylidene]hydrazin-1-yl]carbonyl}phenyl)amino]methyl]-2H-chromen-2-one 
• 1355650-80-4 ethyl 4-{[(7-hydroxy-4-methyl-2-oxo-2H-chromen-8-yl)(4-oxo-4H-chromen-2-yl)methyl]amino}benzoate 
• 1374747-47-3 3-acetyl-5-(2-hydroxybenzoyl)-1-phenyl-1H-pyridin-2-one 
• 1374747-50-8 3-acetyl-5-(2-hydroxybenzoyl)-1-(3-nitrophenyl)-1H-pyridin-2-one 
• 1374747-49-5 3-acetyl-1-(4-chloro-phenyl)-5-(2-hydroxy-benzoyl)-1H-pyridin-2-one 
• 4940-39-0 acide chromone carboxylique-2 
• 33543-90-7 Chromone-2-carbonitrile 
• 330598-06-6 N-(chromone-2-yl-methyl)-benzylamine 

Relevant academic research and scientific papers

Selective C-3 monochlorination of 2-methylchromones and chromone-2- carboxaldehydes

2-methylchromones (1a-d) and chromone-2-carboxaldehydes (3a-d) on reaction with aq. NaOCl yield selectively 3-chlorochromones (2a-d and 4a-d) in yield 61-93%.

Unusual titanium-induced McMurry coupling of 4-oxo-4H-chromene-2-carbaldehydes enroute to bis-chromones

Ti/Zn-mediated McMurry coupling of a series of 4-oxo-4H-chromene-2-carbaldehydes afforded unusual chemoselective CH2-CH2tethered bis-chromones. Studying the reaction parameters and reagents further confirmed that the formation of unexpected coupled products is selective to 4-oxo-4H-chromene-2-carbaldehydes. This methodology demonstrated a simple and efficient route for the synthesis of bis-chromones.

Synthesis and anti-microbial / anti-malarial activity of a new class of chromone-dihydroquinazolinone hybrid heterocycles

A new series of chromone-2,3-dihydroquinazolin-4-one hybrid heterocycles are synthesized from chromone-2-carbaldehydes by coupling with 2-Aminoarylamides and hydrazides without oxidizing agents. The newly synthesized products exhibited moderate to good antimicrobial activity.

Synthesis of 2-dihydrooxadiazolinyl chromones

Reactions of the substituted 2-formyl chromones with aroylhydrazines gave corresponding 2-(aroylhydrazonomethylidyne) chromones. Then 2-(3′-acetyl- 5′-aryl-2′,3′-dihydro-1′,3′,4′-oxadiazol- 2′-yl) chromones were prepared by these 2-(aroylhydrazonomethylidyne) chromones under refluxing with Ac2O. All target compounds were characterized through elemental analysis and IR, 1H NMR, MS.

STUDY OF SUBSTITUTED FORMYLCHROMONES

Substituted derivatives of 2- and 3-formylchromones were synthesized and studied by IR, 13C and 1H NMR spetroscopy and the AM1 quantum chemical method.Energy and electron distribution calculation confirm the preference of synplanar conformation in 3-formylchromones.The calculated charges of the carbon atom correlate well with the experimental 13C chemical shifts.Substituents bonded to the aromatic nucleus have only small effect on the electron structure of the pyrone ring.

Selenium Dioxide Oxidation of Alkylcoumarins and Related Methyl-Substituted Heteroaromatics

By the use of selenium dioxide as the specific oxidizing agent in the coumarin series, the 4-ethyl, 4-propyl and 4-benzyl substituents of coumarin were converted into α-alcohols 2 and/or ketones 3, while 3-methyl- and 3-benzylcoumarins were converted into 3-acyl derivatives 7.The methyl substituent of the analogous thiocoumarin 5, chromones 10 or thiochromone 11 was also oxidized into the formyl functionality.Facile oxidative desulfurization into the ketone functionality, prior to methyl oxidation, was observed for the thione derivatives of 1a, 5, 6 and 10.

THE PREPARATION OF ARYLGLYOXALS AND HETEROAROMATIC ALDEHYDES USING PYRIDONA

Aodium 1-oxido-4,6-diphenyl-2-pyridone reacts with phenacyl halides to give arylglyoxals and with N-heteroarylmethylpyridinium cations to give heteroaromatic aldehydes and ketones.