65161-69-5

Upstream product

• 65161-70-8 3-amino-4-hydroxy-1-methyl-1H-quinolin-2-one; hydrochloride 
• 74-11-3 para-chlorobenzoic acid 
• 78979-62-1 ethyl 2-(4-chlorophenyl)-1,3-oxazole-4-carboxylate 
• 148563-25-1 2-(4-chlorophenyl)oxazolo[4,5-c]quinolin-4(5H)-one 
• 2862-39-7 2-(dimethylamino)ethyl bromide hydrobromide 

Relevant academic research and scientific papers

Rational Design, Synthesis and Evaluation of Oxazolo[4,5-c]-quinolinone Analogs as Novel Interleukin-33 Inhibitors

Interleukin-33 (IL-33) is an epithelial-derived cytokine that plays an important role in immune-mediated diseases such as asthma, atopic dermatitis, and rheumatoid arthritis. Although IL-33 is considered a potential target for the treatment of allergy-rel

Synthesis and reactions of 3-aroyl derivatives of 4-hydroxy-2-quinolones and 4-hydroxycoumarin

3-Aroyl-4-hydroxy-2-quinolones 4 and 11 can be synthesized starting with 1 or 9 via Fries rearrangement of the corresponding esters 3 and 10, catalyzed by potassium cyanide and 18-crown-6. A one pot procedure is presented in which the esters do not need to be isolated. Reduction of the aryl ketones 4 and 11 with zinc dust leads to the benzyl derivatives 5 and 12. Reaction of the aryl ketones 4 and 11 with hydroxylamine and subsequent heating of the crude product leads via thermal Beckmann rearrangement and dehydration to oxazoloquinolones 7 and 14. 2-Aroyloxypyrido[1,2-a]pyrimidin-4-ones 17 and 20 could not be converted to the corresponding ketones by Fries rearrangement.