65169-64-4

Usage

Uses

Used in Pharmaceutical Industry:
4-Pyridinecarboxylic acid, 2-amino-6-methyl-, is used as a T-type calcium channel blocker for the treatment of pruritus. It works by inhibiting the activity of T-type calcium channels, which play a role in the transmission of itch signals in the nervous system. By blocking these channels, the compound can help alleviate the sensation of itching and provide relief for patients suffering from pruritus.

Upstream product

• 25462-85-5 2-chloro-6-methylpyridine-4-carboxylic acid 
• 615-79-2 ethyl 2,4-diketopentanoate 
• 89977-05-9 2-amino-6-methylpyridine-3,4-dicarboxylic acid 
• 91558-58-6 diethyl 2-amino-6-methylpyridine-3,4-dicarboxylate 
• 57508-48-2 carbethoxyacetamidine hydrochloride 

Downstream Products

• 1029128-50-4 2-amino-6-methyl-isonicotinic acid methyl ester 
• 1372127-17-7 C₁₈H₁₄O₈*C₂₇H₃₄ClN₅O₃ 
• 1251528-23-0 C₂₇H₃₄ClN₅O₃ 
• 1251527-64-6 C₂₆H₃₁ClN₄O₄ 

Relevant academic research and scientific papers

One-Pot Synthesis of Substituted 2-Amino Isonicotinic Acids: Reminiscent of the Guareschi-Thorpe Condensation

This work describes a concise manner to make a wide variety of mono- or disubstituted 2-amino isonicotinic acids via the corresponding 2,4-dioxo-carboxylic acid ethyl esters and ethyl 3-amino-3-iminopropionate hydrochloride. The reaction likely proceeds through an in situ decarboxylation process and is reminiscent of the Guareschi-Thorpe Condensation.

A GENERAL PROCESS FOR THE PREPARATION OF 6-SUBSTITUTED OR 5,6-DISUBSTITUTED DERIVATIVES OF 2-AMINO-ISONICOTINIC ACID

This invention relates to a novel synthetic method for the preparation of 6-substituted or 5,6-disubstituted derivatives of 2-amino-isonicotinic acid.

CO-CRYSTALS AND SALTS OF CCR3-INHIBITORS

This invention relates to co-crystals and salts of CCR3 inhibitors of formula (1), pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of diseases related with the CCR3-receptor.

CO-CRYSTALS AND SALTS OF CCR3-INHIBITORS

This invention relates to co-crystals and salts of CCR3 inhibitors of formula 1, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of diseases related with the CCR3-receptor.

SUBSTITUTED PIPERIDINES AS CCR3 ANTAGONISTS

Object of the present invention are novel substituted compounds of the formula 1, wherein A, R1, R2, R3 and R4 are defined as in the description. Another object of the present invention is to provide antagonists of CCR3, more particularly to provide pharmaceutical compositions comprising a pharmaceutically acceptable carrier and a therapeutically effective amount of at least one of the compounds of the present invention or a pharmaceutically acceptable salt thereof.