65171-06-4

Upstream product

• 119138-93-1 (+/-)-4-(3,4,5-trimethoxyphenyl)-3-methoxycarbonylbutanoic acid 
• 84736-30-1 (trimethoxy-3,4,5 benzylidene) α-hemisuccinate de methyle 
• 60546-62-5 6-bromopiperonylic acid 
• 61441-09-6 methyl 6-bromo-1,3-benzodioxole-5-carboxylate 
• 84736-32-3 (bis-methoxycarbonyl-2,3 propen-1 yl-1)-6 methoxycarbonyl-2' methylenedioxy-4',5' trimethoxy-2,3,4 biphenyle 
• 84736-31-2 (bis-methoxycarbonyl-2,3 propene-1 yl-1)-6 methoxycarbonyl-2' methylenedioxy-4',5' trimethoxy-2,3,4 biphenyle (trans) 
• 86-81-7 3,4,5-trimethoxy-benzaldehyde 
• 15930-53-7 6-bromo-3,4-methylenedioxybenzaldehyde 
• 35274-53-4 2-bromo-3,4,5-tri-methoxybenzaldehyde 
• 65171-07-5 trimethoxy-3,4,5 benzylsuccinate de dimethyle 

Downstream Products

• 41451-71-2 (+/-)-steganol 
• 41451-71-2 (+/-)-episteganol 
• 41451-68-7 (+/-)-steganacin 
• 61038-90-2 (+/-)-isostegane 

Relevant academic research and scientific papers

SYNTHESES TOTALES ET ETUDES DE LIGNANES BIOLOGIQUEMENT ACTIFS. APPLICATION DE L'α-HYDROXYALKYLATION DE β-BENZYL γ-BUTYROLACTONES A LA CREATION DES SQUELETTES PHENYL TETRALINE ET BISBENZOCYCLOOCTADIENE - 4. SYNTHESE TOTALE DE LA (+/-)-STEGANONE ET DE SES C

The biphenyl 16 (obtained from α-bromopiperonal and the aromatic iodide 14 by a modified Ullmann reaction) was cyclized by intramolecular hydroxyalkylation to the isomeric alcohols 17a and 17b.These were oxidized using Jones' reagent, to afford the enol 1

SYNTHESES TOTALES ET ETUDES DE LIGNANES BIOLOGIQUEMENT ACTIFS-I. APPLICATION DE LA REACTION D'ULLMANN A LA SYNTHESE DE BIARYLES PRECURSEURS DE LIGNANES BISBENZOCYCLOOCTADIENES

Several biaryls bearing various substituents on both rings were synthesized in a preparativ fashion, and in yields up to 88percent by a technical improvement on the classical Ullmann reaction.All these biaryls bear reactive functional groups (i.e. formyl, methoxycarbonyl, dimethoxycarbonylpropyl and butanolidylmethyl) in both the o and o' positions.The biaryls 9, 13, 21 and 26-33 are plausible synthons for bisbenzocyclooctadiene lignans such as schizandrin and steganacin.