651735-61-4

Basic information

• Product Name: 8-Iodo-1-tetralone
• Synonyms: 8-Iodo-1-tetralone;8-Iodo-α-Tetralone;8-IODO-A-TETRALONE;8-Iodo-3,4-dihydronaphthalen-1(2H)-one
• CAS NO: 651735-61-4
• Molecular Formula: C10H9IO
• Molecular Weight: 272.08233
• Mol File: 651735-61-4.mol

Chemical Properties

• Boiling Point: 345.7 °C at 760 mmHg
• Flash Point: 162.8 °C
• Appearance: /
• Density: 1.757 g/cm³
• Vapor Pressure: 6.07E-05mmHg at 25°C
• Refractive Index: 1.644
• CAS DataBase Reference: 8-Iodo-1-tetralone(CAS DataBase Reference)
• NIST Chemistry Reference: 8-Iodo-1-tetralone(651735-61-4)
• EPA Substance Registry System: 8-Iodo-1-tetralone(651735-61-4)

Safety Data

• Hazardous Substances Data: 651735-61-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
8-Iodo-1-tetralone is used as a key intermediate in the synthesis of various pharmaceuticals for its unique structural and chemical properties that can be further modified to create new drugs.
Used in Organic Chemistry:
8-Iodo-1-tetralone serves as a building block for the production of more complex organic molecules, contributing to the advancement of organic synthesis and the creation of novel compounds with diverse applications.
It is crucial to handle 8-Iodo-1-tetralone with care and follow safety protocols due to its potential reactivity and toxicity, ensuring the safety of researchers and the environment during its use in chemical and pharmaceutical processes. 8-Iodo-1-tetralone remains an active area of research and development within the scientific community, highlighting its significance in modern chemistry.

InChI:InChI=1/C10H9IO/c11-8-5-1-3-7-4-2-6-9(12)10(7)8/h1,3,5H,2,4,6H2

Upstream product

• 2217-41-6 1-amino-5,6,7,8-tetrahydronaphthalene 
• 110139-15-6 N-(8-oxo-5,6,7,8-tetrahydronaphthalen-1-yl)acetamide 
• 6272-18-0 N-(5,6,7,8-tetrahydronaphthalen-1-yl)acetamide 
• 210346-49-9 8-aminotetralone 

Downstream Products

• 1548422-48-5 (S)-methyl 2-[(R)-[(tert-butoxycarbonyl)amino](phenyl)methyl]-8-iodo-1-oxo-1,2,3,4-tetrahydronaphthalene-2-carboxylate 

Relevant articles and documents

CARBAMATE DERIVATIVE COMPOUNDS, PROCESSES FOR PREPARING THEM AND THEIR USES

The present invention relates to a pharmaceutical composition for treating or preventing CNS disorders containing a carbamate derivative compound and/or pharmaceutically acceptable salt thereof as an active ingredient. Furthermore, the present invention relates to a method for treatment or prevention CNS disorders comprising administering a carbamate derivative compound in a pharmaceutically effective amount to a subject in need of treatment or prevention of CNS disorders.

Development of a new family of chiral auxiliaries

A new family of chiral auxiliaries designed on a conformationally restricted version of (-)-8-phenylmenthol has been developed. Both enantiomers are available from an inexpensive synthesis conducted on multigram scale. A first application has showed compa

A Convenient Synthesis of 7-Halo-1-indanones and 8-Halo-1-tetralones

A regioselective oxidation of N-indan-4-yl-acetamide or N-(5,6,7,8-tetrahydronaphthalen-1-yl)acetamide with potassium permanganate followed by acidic hydrolysis gave 7-aminoindan-1-one or 8-aminotetral-1-one in good yield. The amino ketones were converted to the corresponding 7-haloindanone or the 8-halotetralone. Another method to prepare 7-haloindan-1-ones was completed by a cyclization of 3-chloro-1-(2-halophenyl)propan-1-one under Friedel-Crafts conditions to produce the product in gram quantity.