65174-99-4Relevant academic research and scientific papers
Use of 9-(beta-D-arabinofuranosyl) adenine derivatives for the preparation of pharmaceutical compositions for the treatment of aids
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, (2008/06/13)
9-(β-D-arabinofuranosyl)adenine, also commonly known as Ara-A or vidarabine, esters thereof, or a pharmaceutically acceptable salt thereof, possess antiviral activity against the HTLV-III/LAV virus implicated in acquired immune deficiency syndrome (AIDS). The invention is related to the use of compounds of formula I for the preparation of pharmaceutical compositions useful in the treatment of infections of the HTLV-III/LAV virus in patients.
Synthesis and evaluation of a series of 2'-O-acyl derivatives of 9-β-D-arabinofuranosyladenine as antiherpes agents
Baker,Kumar,Waites,Arnett,Shannon,Higuchi,Lambert
, p. 270 - 274 (2007/10/02)
A series of four 9-(2-O-acyl-β-D-arabinofuranosyl)adenines was synthesized by acylation of 9-[3,5-bis-O-(tert-butyldimethylsilyl)-β-D-arabinofuranosyl]adenine followed by removal of the tert-butyldimethylsilyl groups under conditions (HOAc, teta-N-butyammonium fluoride) that prevented acyl migration. The four 2'-O-acyl derivatives showed activity in vitro against herpes type 1 viruses [virus ratings = 1.5-2.6; MIC50 = 26-72 μg/mL (8.48-21.3 x 10-5 M)]. The 2'-O-acetyl (5a) and 2'-O-valeryl derivatives were evaluated in a guinea pig model for genital herpes (herpes type 2); only 5a showed potent activity when given 6 or 24 h postinfection.
