6518-76-9Relevant academic research and scientific papers
Synthesis and biological evaluation of ebselen and its acyclic derivatives
Chang, Tsu-Chung,Huang, Mei-Lan,Hsu, Wen-Lin,Hwang, Jing-Min,Hsu, Ling-Yih
, p. 1413 - 1416 (2007/10/03)
Five ebselen and three acyclic ebselen derivatives were synthesized. These compounds were screened for their glutathione peroxidase (GSH Px)-like activity and scavenging activity against 1,1-diphenyl-2-pycryl-hydrazyl (DPPH) and peroxynitrite radical. All tested compounds displayed similar significant GSH Px-like activity, which are slightly higher than that of ebselen. The peroxynitrite scavenging activity showed that the acyclic allylseleno 4c was five times more potent than ebselen.
