65185-56-0

Upstream product

• 100-46-9 benzylamine 
• 6630-33-7 ortho-bromobenzaldehyde 
• 108791-78-2 N-(2-bromobenzylidene)-1-phenylmethanamine 

Downstream Products

• 59181-46-3 2-benzyl-4-methylene-1,2,3,4-tetrahydroisoquinoline 
• 1040203-89-1 C₂₃H₂₀N₂ 
• 1196709-03-1 (S)-4-benzyl-2-methyl-4,5-dihydro-1H-benzo[e][1,4]-diazepin-3(2H)-one 
• 1196708-88-9 (S)-4-benzyl-2-isopropyl-4,5-dihydro-1H-benzo[e][1,4]-diazepin-3(2H)-one 
• 1196709-05-3 (S)-2,4-dibenzyl-4,5-dihydro-1H-benzo[e][1,4]-diazepin-3(2H)-one 
• 1196709-07-5 (S)-4-benzyl-2-(4-hydroxybenzyl)-4,5-dihydro-1H-benzo[e][1,4]-diazepin-3(2H)-one 
• 1196708-76-5 (S)-5-benzyl-1,2,3,3a,5,6-hexahydrobenzo[f]pyrrolo-[1,2-a][1,4]diazepin-4-one 
• 1196709-09-7 (S)-2-((1H-indol-3-yl)methyl)-4-benzyl-4,5-dihydro-1H-benzo[e][1,4]-diazepin-3(2H)-one 
• 937648-85-6 ethyl 2-benzyl-1,2,3,4-tetrahydroisoquinolidine-4-carboxylate 
• 1334296-11-5 ethyl 3-[benzyl(2-bromobenzyl)amino]-2-methylpropanoate 
• 1334295-98-5 ethyl N-benzyl-N-(2-bromobenzyl)-β-alaninate 
• 1431859-12-9 N-benzyl-N-((2-bromobenzyl)-5-methyl-1-phenyl)hex-1-yn-3-amine 
• 1431858-96-6 3-phenyl-4-(2'methylpropyl)-5-benzyl-5,6-dihydro-4H-[1,2,3]triazolo[1,5-a][1,4]benzodiazepine 
• 1431859-05-0 N-benzyl-N-(2-bromobenzyl)-1-phenyloct-1-yn-3-amine 

Relevant academic research and scientific papers

Microwave-Assisted Palladium-Catalyzed Reductive Cyclization/Ring-Opening/Aromatization Cascade of Oxazolidines to Isoquinolines

An efficient palladium-catalyzed reaction of N-propargyl oxazolidines for the construction of 4-substituted isoquinolines under microwave irradiation is developed. This transformation proceeds through a sequential palladium-catalyzed reductive cyclization/ring-opening/aromatization cascade via C-O and C-N bond cleavages of the oxazolidine ring. The practical value of this method has also been explored by conducting a millimole-scale reaction, as well as by transforming the isoquinoline into a key intermediate for the synthesis of a lamellarin analogue.

A simple efficient sequential one-pot intermolecular aza-Michael addition and intramolecular Buchwald-Hartwig α-arylation of amines: Synthesis of functionalized tetrahydroisoquinolines

An efficient one-pot sequential intermolecular aza-Michael addition and Pd-catalyzed intramolecular Buchwald-Hartwig α-arylation of secondary amines have been investigated, for the synthesis of tetrahydroisoquinolines. This method is simple and furnished

Palladium-mediated intramolecular Buchwald-Hartwig α-arylation of β-amino esters: Synthesis of functionalized tetrahydroisoquinolines

A concise and efficient three-step strategy for the synthesis of functionalized 1,2,3,4-tetrahydroisoquinolines based on an intramolecular Buchwald-Hartwig α-arylation of β-amino esters is described. The synthesis presented is operationally simple and is amenable for the synthesis of a number of analogues. Georg Thieme Verlag Stuttgart · New York.

Synthesis and antitumor evaluation of a novel class of 4-substituted-1,4- dihydroisoquinolin-3-ones

An efficient method for the solution-phase parallel synthesis of 4-substituted-1,4-dihydroisoquinolin-3-ones is developed. The isoquinolinones were constructed employing an intramolecular Heck reaction, providing full regio- and stereoselectivity. Most of