6519-10-4Relevant academic research and scientific papers
Cascade Process for Direct Transformation of Aldehydes (RCHO) to Nitriles (RCN) Using Inorganic Reagents NH2OH/Na2CO3/SO2F2 in DMSO
Fang, Wan-Yin,Qin, Hua-Li
, p. 5803 - 5812 (2019/05/14)
A simple, mild, and practical process for direct conversion of aldehydes to nitriles was developed feathering a wide substrate scope and great functional group tolerability (52 examples, over 90% yield in most cases) using inorganic reagents (NH2OH/Na2CO3/SO2F2) in DMSO. This method allows for transformations of readily available, inexpensive, and abundant aldehydes to highly valuable nitriles in a pot, atom, and step-economical manner without transition metals. This protocol will serve as a robust tool for the installation of cyano-moieties to complicated molecules.
Stereoarrayed 2,3-Disubstituted 1-Indanols via Ruthenium(II)-Catalyzed Dynamic Kinetic Resolution-Asymmetric Transfer Hydrogenation
Cotman, Andrej Emanuel,Modec, Barbara,Mohar, Barbara
supporting information, p. 2921 - 2924 (2018/05/28)
Activated racemic 2,3-disubstituted 1-indanones 1 possessing two stereolabile centers were stereoselectively reduced to the corresponding chiral 2,3-disubstituted-1-indanols 2 by ruthenium(II)-catalyzed dynamic kinetic resolution-asymmetric transfer hydro
Direct synthesis of α,β-unsaturated nitriles in solid/liquid heterogeneous medium
Ladhar,El Gharbi
, p. 413 - 417 (2007/10/02)
α,β-unsaturated nitriles are obtained with high yields by condensation of diversely substituted aldehydes using nitriles in the presence of K2CO3. These basic active species avoids aldolisation generally observed in this type of reaction.
