65190-50-3

Usage

Chemical compound

2,5-Pyrrolidinedione, 1-[[4-(bromomethyl)benzoyl]oxy]-

Structure

Consists of a pyrrolidinedione ring with a benzoyloxy substituent at the 1-position and a bromomethyl group attached to the benzoyloxy moiety

Usage

Commonly used as a building block in the synthesis of organic compounds, especially in the pharmaceutical and agrochemical industries

Applications

Can be used as a precursor for the production of pharmaceutical drugs, agrochemicals, and other fine chemicals

Value

Its unique structure and reactivity make it a valuable tool for synthetic chemistry and drug discovery research

Safety

Important to handle with caution, as exposure may lead to adverse health effects.

Upstream product

• 6066-82-6 1-hydroxy-pyrrolidine-2,5-dione 
• 6232-88-8 4-bromomethylbenzoic Acid 

Downstream Products

• 118507-18-9 4-(bromomethyl)-N-methylbenzamide 
• 118507-19-0 4-Bromomethyl-N-butyl-benzamide 
• 118507-20-3 N-phenethyl-p-bromomethylbenzamide 
• 118507-21-4 1-[2-(4-bromomethylphenylcarboxamide)ethyl]-4-hydroxybenzene 

Relevant academic research and scientific papers

Direct18F-Labeling of Biomolecules via Spontaneous Site-Specific Nucleophilic Substitution by F-on Phosphonate Prostheses

We describe a high radiochemical yield late-stage direct 18F-labeling of bare biomolecules containing common active groups. Spontaneity and site-selectivity are attributed to the remarkably higher rates of nucleophilic substitution reactions on phosphonates than on other electrophiles by F- at various hydrogen bond forms. Rapid access to many medicinally significant 18F-labeled biomolecules is achieved at 21-68% radiochemical yields and 35.9-55.1 GBq μmol-1 molar activities both manually or automatically.

Process for introducing fluorine into biologically active materials

Radioactive fluorine can be easily introduced into biologically active molecules containing amino groups. A p-bromomethyl benzoyl group is coupled to the amino group of the biologically active molecule, and bromine is displaced by fluorine. Alternatively,

Rifamycins as inhibitors of retroviral reverse transcriptase from M-MuLV, RAV-2, and HIV-1

29 Rifamycins were tested for inhibition of Reverse Transcriptase (RT) as potential anti HIV drugs. Two purified commercial enzymes from M-MuLV and RAV-2 were used. Anti-RT activity was also measured on a crude lysate of HIV-1. The results show that some derivatives have interesting levels of activity on isolated M-MuLV and RAV-2 RTs, while they are less active on the RT in the crude HIV-1 lysate. The active derivatives include oximes and hydrazones, alkylaminoderivatives, open ansa-chain derivatives and derivatives carrying a modified nucleoside.

A PROSTHETIC GROUP FOR THE RAPID INTRODUCTION OF FLUORINE INTO PEPTIDES AND FUNCTIONALIZED DRUGS

Fluoride ion as the tetrabutylammonium salt displaces bromide in para-substituted benzyl bromides in acetonitrile or dimethylformamide.The p-bromomethyl benzoyl (BMB) group has been coupled to amino groups, including peptide amino groups, via its N-hydrox