65195-20-2Relevant academic research and scientific papers
Iron-Catalyzed Direct Alkylamination of Phenols with O-Benzoyl-N-alkylhydroxylamines under Mild Conditions
Jia, Lei,Gao, Sen,Xie, Junyao,Luo, Meiming
, p. 3840 - 3846 (2016/12/16)
A novel iron-catalyzed direct alkylamination reaction of phenols has been achieved with O-benzoyl-N-alkylhydroxylamines as aminating agents. This protocol provides a facile access to N-alkyl-substituted aminophenols though a radical reaction from phenols. The catalytic direct alkylamination operates at room temperature without the need of any ligands and additives to afford the desired products with excellent regioselectivity and functional group tolerance. (Figure presented.).
4,5-DIHYDROISOXAZOLE DERIVATIVES AS NAMPT INHIBITORS
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Page/Page column 212; 213, (2014/08/06)
The present invention provides substituted 4,5-dihydroisoxazole derivatives of formula (I), which may be therapeutically useful, more particularly NAMPT inhibitors and in which R1 R2, Y, X, "Het" and "p" have the meanings given in the specification, and pharmaceutically acceptable salts thereof that are useful in the treatment and prevention of diseases or disorder caused by an elevated level of nicotinamide phosphoribosyltransferase (NAMPT) in a mammal. The present invention also provides preparation of the compounds and pharmaceutical formulations comprising at least one of the substituted 4,5-dihydroisoxazole derivatives of formula (I) or a pharmaceutically acceptable salts or stereoisomers or N-oxide thereof.
