652-69-7

Basic information

• Product Name: 17ALPHA, 20ALPHA-DIHYDROXY-4-PREGNEN-3-ONE
• Synonyms: 17ALPHA, 20ALPHA-DIHYDROXY-4-PREGNEN-3-ONE;4-PREGNEN-17ALPHA, 20ALPHA-DIOL-3-ONE;4-PREGNEN-17A, 20A-DIOL-3-ONE;4-pregnene-17A,20A-diol-3-one;17a, 20a-Dihydroxy-4-pregnen-3-one;(20S)-17,20-dihydroxy-Pregn-4-en-3-one;3alpha,7alpha-Dihydroxy-5beta-cholestanate;(8R,9S,10R,13S,14S,17R)-17-hydroxy-17-[(1S)-1-hydroxyethyl]-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one
• CAS NO: 652-69-7
• Molecular Formula: C₂₁H₃₂O₃
• Molecular Weight: 332.48
• Product Categories: Steroids & Hormones - 13C & 2H;Steroids
• Mol File: 652-69-7.mol

Chemical Properties

• Melting Point: 204-206°C
• Boiling Point: 487.1°C at 760 mmHg
• Flash Point: 262.5°C
• Appearance: /
• Density: 1.15g/cm³
• Vapor Pressure: 1.56E-11mmHg at 25°C
• Refractive Index: 1.567
• Storage Temp.: -20°C Freezer
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• PKA: 14.79±0.60(Predicted)
• Stability: Store in Fridge
• CAS DataBase Reference: 17ALPHA, 20ALPHA-DIHYDROXY-4-PREGNEN-3-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 17ALPHA, 20ALPHA-DIHYDROXY-4-PREGNEN-3-ONE(652-69-7)
• EPA Substance Registry System: 17ALPHA, 20ALPHA-DIHYDROXY-4-PREGNEN-3-ONE(652-69-7)

Safety Data

• Hazardous Substances Data: 652-69-7(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

Uses

4-Pregnen-17α, 20α-diol-3-one (cas# 652-69-7) is a compound useful in organic synthesis.

InChI:InChI=1/C21H32O3/c1-13(22)21(24)11-8-18-16-5-4-14-12-15(23)6-9-19(14,2)17(16)7-10-20(18,21)3/h12-13,16-18,22,24H,4-11H2,1-3H3/t13-,16+,17-,18-,19-,20-,21-/m0/s1

Upstream product

• 68-96-2 17-hydroxy-progesterone 
• 57-83-0 Progesterone 

Downstream Products

• 68-96-2 17-hydroxyprogesterone 

Relevant articles and documents

Oxidation of 17α,20β- and 17α,20α-dihydroxypregn-4- en-3-ones, side products of progesterone biotransformation with recombinant microorganisms expressing cytochrome P-45017α

Progesterone biotransformation with recombinant yeasts Yarrowia lipolytica E129A15 and Saccharomyces cerevisiae GRF18/YEp5117α expressing bovine adrenocortical cytochrome P-45017α yielded 17α-hydroxyprogesterone and two diols, 17α,20β- and 17α,20α-dihydroxypregn-4-en- 3-ones. The oxidation of mixtures of the three steroids with chromic acid resulted in the cleavage of 17-20 bonds in the diols with the formation of androst-4-ene-3,17-dione. The biotransformation of pregn-4-ene-20β-ol-3-one by means of Y. lipolytica E129A15 was accompanied by the following reactions: the primary oxidation of these compounds to progesterone and the subsequent successive reactions of 17α-hydroxylation and 20α- and 20β-reduction. The results widen the possibilities of enzymatic and chemical modifications of steroids.