65208-12-0

Basic information

• Product Name: (3-CHLORO-2-METHYLPHENYL)HYDRAZINE HYDROCHLORIDE
• Synonyms: (3-CHLORO-2-METHYLPHENYL)HYDRAZINE HYDROCHLORIDE;1-(3-CHLORO-2-METHYLPHENYL)HYDRAZINE HYDROCHLORIDE;BIO-FARMA BF000375;2-Chloro-6-hydrazinotoluene hydrochloride
• CAS NO: 65208-12-0
• Molecular Formula: C₇H₉ClN₂*ClH
• Molecular Weight: 193.07
• Product Categories: Aromatic Hydrazides, Hydrazines, Hydrazones and Oximes
• Mol File: 65208-12-0.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (3-CHLORO-2-METHYLPHENYL)HYDRAZINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: (3-CHLORO-2-METHYLPHENYL)HYDRAZINE HYDROCHLORIDE(65208-12-0)
• EPA Substance Registry System: (3-CHLORO-2-METHYLPHENYL)HYDRAZINE HYDROCHLORIDE(65208-12-0)

Safety Data

• Hazard Codes: Xi,T
• Statements: 25
• Safety Statements: 45
• HazardClass: IRRITANT
• Hazardous Substances Data: 65208-12-0(Hazardous Substances Data)

Usage

General Description

(3-Chloro-2-methylphenyl)hydrazine hydrochloride is a chemical compound with the molecular formula C7H10Cl2N2. It is a hydrazine derivative with a chlorine-substituted phenyl ring, and it exists in the form of a hydrochloride salt. (3-CHLORO-2-METHYLPHENYL)HYDRAZINE HYDROCHLORIDE is commonly used as a reactant in chemical synthesis, particularly in the preparation of pharmaceuticals and agrochemicals. It has also been studied for its potential antiviral and anticancer properties. Additionally, (3-chloro-2-methylphenyl)hydrazine hydrochloride has been evaluated for its ability to inhibit the growth of certain bacteria and fungi, making it a valuable compound for research and development in the fields of medicine and agriculture.

Upstream product

• 87-60-5 3-chloro-2-methylbenzenamine 

Downstream Products

• 77635-44-0 N-(3-Chloro-2-methyl-phenyl)-N'-[1-(3-nitro-phenyl)-eth-(E)-ylidene]-hydrazine 
• 1639789-07-3 4-chloro-2-(1-(3-chloro-2-methylphenyl)-1H-pyrazol-4-yl)-3,3,7-trimethyl-3H-indole 
• 77635-74-6 N-(3-Chloro-2-methyl-phenyl)-N'-[1-(4-nitro-phenyl)-eth-(E)-ylidene]-hydrazine 
• 77635-65-5 N-(3-Chloro-2-methyl-phenyl)-N'-[1-(2-trifluoromethyl-phenyl)-eth-(E)-ylidene]-hydrazine 
• 77635-96-2 N-(3-Chloro-2-methyl-phenyl)-N'-[2,2,2-trifluoro-1-phenyl-eth-(Z)-ylidene]-hydrazine 

Relevant articles and documents

Synthesis and biological evaluation of (1-aryl-1H-pyrazol-4-yl) (3,4,5-trimethoxyphenyl)methanone derivatives as tubulin inhibitors

A series of (1-aryl-1H-pyrazol-4-yl) (3,4,5-trimethoxyphenyl)methanones (8a-p, 9a-p) and ketoxime (10c) derivatives were designed and synthesized as antitubulin agents. All of the target compounds were evaluated for the in vitro anti-proliferative activities against three tumor cell lines (A549, HT-1080, SGC-7901). The most promising compounds in this class were (1-(p-tolyl)-1H-pyrazol-4-yl) (3,4,5-trimethoxyphenyl)methanone (9c) and its ketoxime derivative (10c), which significantly inhibited tumor cells growth with IC50 value of 0.054–0.16 μM. Meanwhile, compound 9c exhibited effectively inhibitory activity of tubulin polymerization. Consistent with its antitubulin activity, compound 9c could destructively damage microtubule network and arrest SGC-7901 cell cycle at G2/M phase significantly. The structure-activity relationship (SAR) and conformational analysis indicate that methyl group at C4-position of C-ring is critical for the activities and the amino group at the C5-position of B-ring plays a negative role in maintaining bioactivity. Furthermore, a molecular docking study was performed to elucidate its binding mode at the colchicine site in the tubulin heterodimer.