65208-12-0

Basic information

• Product Name: (3-CHLORO-2-METHYLPHENYL)HYDRAZINE HYDROCHLORIDE
• Synonyms: (3-CHLORO-2-METHYLPHENYL)HYDRAZINE HYDROCHLORIDE;1-(3-CHLORO-2-METHYLPHENYL)HYDRAZINE HYDROCHLORIDE;BIO-FARMA BF000375;2-Chloro-6-hydrazinotoluene hydrochloride
• CAS NO: 65208-12-0
• Molecular Formula: C₇H₉ClN₂*ClH
• Molecular Weight: 193.07
• Product Categories: Aromatic Hydrazides, Hydrazines, Hydrazones and Oximes
• Mol File: 65208-12-0.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (3-CHLORO-2-METHYLPHENYL)HYDRAZINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: (3-CHLORO-2-METHYLPHENYL)HYDRAZINE HYDROCHLORIDE(65208-12-0)
• EPA Substance Registry System: (3-CHLORO-2-METHYLPHENYL)HYDRAZINE HYDROCHLORIDE(65208-12-0)

Safety Data

• Hazard Codes: Xi,T
• Statements: 25
• Safety Statements: 45
• HazardClass: IRRITANT
• Hazardous Substances Data: 65208-12-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Synthesis:
(3-CHLORO-2-METHYLPHENYL)HYDRAZINE HYDROCHLORIDE is used as a reactant in the synthesis of pharmaceuticals, leveraging its chemical properties to contribute to the development of new medications.
Used in Agrochemical Production:
In the agrochemical industry, (3-CHLORO-2-METHYLPHENYL)HYDRAZINE HYDROCHLORIDE is utilized as a reactant for the preparation of various agrochemicals, potentially enhancing crop protection and yield.
Used in Antiviral Research:
(3-CHLORO-2-METHYLPHENYL)HYDRAZINE HYDROCHLORIDE is used as a subject of study in antiviral research, exploring its potential to combat viral infections and contribute to the development of antiviral agents.
Used in Anticancer Research:
(3-CHLORO-2-METHYLPHENYL)HYDRAZINE HYDROCHLORIDE is also used in anticancer research, investigating its properties to understand its possible role in inhibiting cancer cell growth and the advancement of cancer treatment options.
Used in Antibacterial and Antifungal Applications:
(3-CHLORO-2-METHYLPHENYL)HYDRAZINE HYDROCHLORIDE has been evaluated for its ability to inhibit the growth of certain bacteria and fungi, making it a valuable compound for research and development in creating new antimicrobial agents for medical and agricultural use.

Upstream product

• 87-60-5 3-chloro-2-methylbenzenamine 

Downstream Products

• 77635-96-2 N-(3-Chloro-2-methyl-phenyl)-N'-[2,2,2-trifluoro-1-phenyl-eth-(Z)-ylidene]-hydrazine 
• 77635-65-5 N-(3-Chloro-2-methyl-phenyl)-N'-[1-(2-trifluoromethyl-phenyl)-eth-(E)-ylidene]-hydrazine 
• 1639789-07-3 4-chloro-2-(1-(3-chloro-2-methylphenyl)-1H-pyrazol-4-yl)-3,3,7-trimethyl-3H-indole 
• 77635-44-0 N-(3-Chloro-2-methyl-phenyl)-N'-[1-(3-nitro-phenyl)-eth-(E)-ylidene]-hydrazine 
• 77635-74-6 N-(3-Chloro-2-methyl-phenyl)-N'-[1-(4-nitro-phenyl)-eth-(E)-ylidene]-hydrazine 

Relevant articles and documents

Synthesis and biological evaluation of (1-aryl-1H-pyrazol-4-yl) (3,4,5-trimethoxyphenyl)methanone derivatives as tubulin inhibitors

A series of (1-aryl-1H-pyrazol-4-yl) (3,4,5-trimethoxyphenyl)methanones (8a-p, 9a-p) and ketoxime (10c) derivatives were designed and synthesized as antitubulin agents. All of the target compounds were evaluated for the in vitro anti-proliferative activities against three tumor cell lines (A549, HT-1080, SGC-7901). The most promising compounds in this class were (1-(p-tolyl)-1H-pyrazol-4-yl) (3,4,5-trimethoxyphenyl)methanone (9c) and its ketoxime derivative (10c), which significantly inhibited tumor cells growth with IC50 value of 0.054–0.16 μM. Meanwhile, compound 9c exhibited effectively inhibitory activity of tubulin polymerization. Consistent with its antitubulin activity, compound 9c could destructively damage microtubule network and arrest SGC-7901 cell cycle at G2/M phase significantly. The structure-activity relationship (SAR) and conformational analysis indicate that methyl group at C4-position of C-ring is critical for the activities and the amino group at the C5-position of B-ring plays a negative role in maintaining bioactivity. Furthermore, a molecular docking study was performed to elucidate its binding mode at the colchicine site in the tubulin heterodimer.