652155-32-3

Upstream product

• 112137-99-2 (1R,2S)-2-(isopropylamino)-1-phenyl-1-propanol 
• 492-41-1 (1R,2S)-norephedrine 
• 96228-13-6 (1R,2S)-2-Isopropylideneamino-1-phenyl-propan-1-ol 

Downstream Products

• 652155-36-7 (4R,5S,6R)-3,4,5,6-tetrahydro-3-[(2S,3S)-3-hydroxy-2-methyl-3-phenylpropionyl]-4-isopropyl-5-methyl-6-phenyl-2H-1,3,4-oxadiazin-2-one 
• 652155-35-6 (4R,5S,6R)-4-isopropyl-5-methyl-6-phenyl-3-[3-(phenylthio)propionyl]-3,4,5,6-tetrahydro-2H-1,3,4-oxadiazin-2-one 
• 652155-34-5 (4R,5S,6R)-3,4,5,6-tetrahydro-4-isopropyl-5-methyl-6-phenyl-3-propionyl-2H-1,3,4-oxadiazin-2-one 
• 652155-33-4 (5S,6R)-3,4,5,6-tetrahydro-4-isopropyl-5-methyl-6-phenyl-2H-1,3,4-oxadiazin-2-one 
• 652155-47-0 (1R,2S)-2-(N-Isopropyl-hydrazino)-1-phenyl-propan-1-ol 

Relevant academic research and scientific papers

Intramolecular Chiral Relay at Stereogenic Nitrogen. Synthesis and Application of A New Chiral Auxiliary Derived from (1R,2S)-Norephedrine and Acetone

(1R,2S)-Norephedrine has been employed in the synthesis of a novel 3,4,5,6-tetrahydro-2H-1,3,4-oxadiazin-2-one via reductive alkylation with acetone, N-nitrosation, reduction, and cyclization. The oxadiazinone was treated with either propionyl chloride or