65219-31-0Relevant academic research and scientific papers
Metal-free oxidative cyclization of acetophenones with diamines: A facile access to phenylpyridines
Sharma, Rohit,Patel, Neha,Vishwakarma, Ram A.,Bharatam, Prasad V.,Bharate, Sandip B.
supporting information, p. 1009 - 1012 (2016/01/16)
An efficient metal-free access to 2- and 3-phenylpyridines via oxidative coupling of acetophenones or phenylacetones with 1,3-diaminopropane has been described. The reaction involves shorter reaction time, excellent yields and a broad substrate scope. The reaction proceeds via the formation of imine, which further undergoes oxidative C-N bond cleavage, C-C bond formation and oxidation to give a pyridine skeleton. The quantum chemical calculations identified the transition state for the reaction and helped in tracing the reaction mechanism.
