65242-18-4Relevant academic research and scientific papers
A convenient preparation of diversely substituted fused 2-amino- and 2-alkylthionicotinonitriles under microwave irradiation
Krasavin, Mikhail,Sapegin, Alexander,Dorogov, Mikhail
, p. 56 - 60 (2015/02/05)
We describe a convenient and operationally simple protocol to prepare nicotinonitriles fused to either a cycloalkane or a saturated heterocycle, containing diverse substituents at position 2 of the nicotinonitrile core, under microwave irradiation. The protocol is useful for rapid and automated synthesis of the target compounds. An unusual case of the loss of a tert-butyl group is observed when tert-butylamine was used to bring about the pyridine ring formation.
Synthesis of substituted 2-aminonicotinonitriles
Troschutz,Dennstedt
, p. 33 - 40 (2007/10/02)
Mono-, di-, and trisubstituted 2-aminonicotinonitriles 8, 13, 14, and 19 are prepared from ketonic Mannich-bases hydrochlorides 4 · HCl, enones 12, β-aminovinylketones 17, 3-aminoacroleines 18, vinamidinium perchlorates 21, and 3,3-diaminoacrylonitrile (3
A New Route to 2-Amino- or 2-Hydroxy-3-pyridinecarboxylic Acid Derivatives
Ito, Kunio,Yokokura, Seiichi,Miyajima, Shingo
, p. 773 - 778 (2007/10/02)
Schiff's bases derived from ketones and t-butylamine (1) reacted with methyl methoxymethylenemalonate to give 2-hydroxy-3-pyridinecarboxylates.Similarly, treatment of 1 with ethoxymethylenemalononitrile gave 2-amino-3-pyridinecarbonitriles.Compounds 1 on reaction with ethyl 2-cyano-3-ethoxypropenoate afforded 2-amino-3-pyridinecarboxylates.
