65263-09-4

Upstream product

• 23080-22-0 bis(2-(4-methylphenyl)ethanonyl)sulfide 
• 325850-77-9 2-(4,5-dihydro-1,3-thiazol-2-ylsulfanyl)-1-(4-methylphenyl)-1-ethanone 
• 619-41-0 4-(bromoacetyl)toluene 
• 6097-27-4 2-thiocyanato-1-(4-tolyl)ethanone 

Downstream Products

• 74141-83-6 2,7-dihydro-3,6-di-p-tolyl-1,4,55-thiadiazepine 1,1-dioxide 
• 34102-87-9 3,6-bis(4-methylphenyl)pyridazine 

Relevant academic research and scientific papers

Preparation of 3,6-Disubstituted Pyridazines from 3-Thiapentane-1,5-diones via 2,7-Dihydro-1,4,5-thiadiazepines

A series of 3-thiapentane-1,5-diones condense with hydrazine in the presence of a catalytic amount of p-toluenesulfonic acid in refluxing ethanol to give 2,7-dihydro-1,4,5-thiadiazepines in excellent yields.Thermal decomposition of the latter compounds in

Synthesis of 3,6-diaryl-1,4,5-thiadiazepines from substituted 2-thiocyano acetophenone and investigation of reaction mechanism

In this work, we have studied the reaction of substituted 2-thiocyanoacetophenone and hydrazine hydrate as a novel and simple pathway for the preparation of the substituted 1,4,5-thiodiazepine ring system. The mechanism of this reaction revealed that in the initial step condensation of hydrazine with carbonyl groups of substituted 2-thiocyanoacetophenons 2a-2f gives the corresponding substituted aromatic dithiocyano azide intermediates which in turn undergo cyclization to1,4,5-thiadiazepines in the presence of hydrazine. This cyclization is a novel method for the preparation of sulfide bond from the reaction of hydrazine and a dithiocyano intermediate. An account of the reaction mechanism is given.

Formation of reagent-selective products from 2-(4,5-dihydrothi- azol-2-ylthio)-1-arylethanone with different nucleophiles

The reactions of 2-(4,5-dihydrothiazol-2-ylthio)-1-arylethanone with different nucleophiles including semicarbazide hydrochloride, hydroxylamine hydrochloride, hydrazine, ethylenediamine and aminoethanol have been investigated, and the formation of a variety of products with different reagents is highlighted.

Facile Syntheses of 1,4,5-Thiadiazepine, 1,4,7-Thiadiazonine, Imidazothiazine and Pyrimidothiazine

The condensation of diphenacyl sulphides with hydrazine hydrate, 1,2-diaminoethane, 1,2-diaminopropane and 1,3-diaminopropane, performed in ethylene glycol-ethanol (3: 2) medium provides convenient syntheses of 3,6-diaryl-2,7-dihydro-1,4,5-thiadiazepine (