65287-74-3

Basic information

• Product Name: 1-(2-Chloro-1H-indol-3-yl)-ethanone
• Synonyms: 1-(2-Chloro-1H-indol-3-yl)-ethanone
• CAS NO: 65287-74-3
• Molecular Formula: C₁₀H₈ClNO
• Molecular Weight: 193.62962
• EINECS: -0
• Mol File: 65287-74-3.mol
• Article Data: 11

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-(2-Chloro-1H-indol-3-yl)-ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-Chloro-1H-indol-3-yl)-ethanone(65287-74-3)
• EPA Substance Registry System: 1-(2-Chloro-1H-indol-3-yl)-ethanone(65287-74-3)

Safety Data

• Hazardous Substances Data: 65287-74-3(Hazardous Substances Data)

Usage

Chemical structure

A ketone derivative containing a chloro-substituted indole ring

Pharmaceutical industry

As an intermediate for the production of various drugs

Organic synthesis

As a building block for the synthesis of more complex chemical compounds

Research applications

Study of indole-based compounds and their potential biological activities

Role in industry

Crucial in the development of new and advanced chemical compounds for various industries

Upstream product

• 59-48-3 2-oxoindole 
• 127-19-5 N,N-dimethyl acetamide 

Downstream Products

• 213591-09-4 1-{1-(methoxymethyl)-2-[(triphenylphosphoranylidene)amino]indol-3-yl}ethanone 
• 172869-90-8 N-benzyl-2-chloro-3-acetyl-indole 
• 1311380-65-0 C₂₂H₂₀ClNO 
• 1311380-66-1 C₂₂H₂₀ClNO₂ 
• 1311380-67-2 C₂₁H₁₇Cl₂NO 
• 1311380-68-3 C₂₂H₂₀ClNO 
• 1311380-64-9 1-(2-chloro-1-(5-phenylpent-4-ynyl)indol-3-yl)ethanone 
• 1352632-34-8 C₂₀H₁₇Cl₂NO 
• 1352632-32-6 C₂₁H₂₀ClNO₂ 
• 1352632-20-2 C₂₁H₁₉Cl₂NO 
• 1352632-28-0 C₂₀H₁₈ClNO 
• 1352632-25-7 C₂₂H₂₁ClFNO 
• 1185994-28-8 3-methyl-1-phenyl-1,8-dihydropyrazolo[3,4-b]indole 

Relevant articles and documents

Fused indoles. 1. Synthesis of the 1,9-dihydrothiazino[3,4-b]indole ring system

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Photoinduced chlorine atom-transfer cyclization/photohydrolysis of 3-acyl-2-chloro-N-(ω-phenylalkynyl)pyrroles: A one-pot synthesis of benzoyl-substituted fused pyrroles

A one-pot synthesis of benzoyl-substituted fused pyrroles or indoles in moderate to high yields has been achieved by the photocyclization/ photohydrolysis reactions of N-(ω-phenylalkynyl)-2-chloropyrrole-3- carbaldehydes or 3-acyl-N-(ω-phenylbutynyl)-2-haloindoles in wet acetone. The formation of all these products could be inferred by a two-step reactions, namely, photoinduced chlorine atom-transfer cyclization and subsequent photohydrolysis.

One-pot synthesis of fused benzo[c]carbazoles by photochemical intramolecular annulation of 3-acyl-2-haloindoles with tethered styrenes

An efficient procedure for the synthesis of fused benzo[c]carbazoles has been achieved in moderate to high yields by the one-pot photochemical annulation of 3-acyl-2-haloindoles with tethered styrenes by photoinduced electron-transfer coupling, electrocyclic reactions, and deacylative aromatization in the presence of pyridine. Fused furo[2,3-c]carbazoles were also synthesized under the same conditions. 5,6-Dihydrobenzo[c]pyrrolo[1,2,3-lm] carbazoles were oxidized by DDQ to afford aromatic benzo[c]pyrrolo[1,2,3-lm] carbazole products in moderate to high yields.