65296-14-2

Upstream product

• 122-01-0 4-chloro-benzoyl chloride 
• 21384-46-3 (4-chlorophenyl)(2-methylaziridin-1-yl)methanone 
• 104-88-1 4-chlorobenzaldehyde 
• 78-96-6 3-amino-2-propanol 
• 5866-99-9 4-chloro-N-(prop-2-en-1-yl)benzamide 

Relevant academic research and scientific papers

Transition metal and base free synthesis of 2-aryl-2-oxazolines from aldehydes and β-amino alcohols catalysed by potassium iodide

Synthesis of 2-aryl-2-oxazolines from β-amino alcohols and aldehydes was achieved in good to excellent yield by employing a potassium iodide (KI)-tert-butyl hydroperoxide (TBHP) catalytic system. This protocol is very mild, metal and base free and can be performed under ambient reaction conditions. This oxidative cyclization strategy was further extended for the synthesis of optically active 2-oxazolines, which can act as very useful chiral auxiliaries and as ligands. This journal is

Phosphine-catalyzed heine reaction

Aziridines are important synthetic intermediates which readily undergo ring-opening reactions. It is demonstrated that electron-rich phosphines are efficient catalysts for the regioselective rearrangement of N-acylaziridines to oxazolines. The reactions o