652987-35-4Relevant academic research and scientific papers
Discovery of selective phosphonamide-based inhibitors of tumor necrosis factor-α converting enzyme (TACE)
Sawa, Masaaki,Kurokawa, Kiriko,Inoue, Yoshimasa,Kondo, Hirosato,Yoshino, Kohichiro
, p. 2021 - 2024 (2007/10/03)
A novel series of phosphonamide-based inhibitors of tumor necrosis factor-α converting enzyme (TACE) was discovered by structural modification of tetrahydroisoquinoline derivative 1b, which was extremely weak inhibitor of TACE. (S)-Isomer at the phosphorus atom (7b) displayed potent inhibition for TACE, while selectivity sparing MMP-1, -3, and -9.
